Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors

  • Authors:
    • Y Yang
  • View Affiliations

  • Published online on: December 1, 1996     https://doi.org/10.3892/ijo.9.6.1259
  • Pages: 1259-1265
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In this study, we examined the effect of antisense neu recombinant murine retroviral vectors on the p185 expression in B104-1 cells. Two fragments containing the 5' end and the transmembrane region of neu* were inserted in an inverted orientation relative to the 5' long terminal repeat (LTR) of the pDOL retroviral vector and used in transfecting B104-1 cells. The results obtained from RNAse protection assays were not consistent with the proposed mechanism of the antisense action by other investigators. Elevated expression of p185 was observed in several antisense vector-transfected clones, presumably caused by the promoter-insertion type of activation.

Related Articles

Journal Cover

December 1996
Volume 9 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y: Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors. Int J Oncol 9: 1259-1265, 1996
APA
Yang, Y. (1996). Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors. International Journal of Oncology, 9, 1259-1265. https://doi.org/10.3892/ijo.9.6.1259
MLA
Yang, Y."Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors". International Journal of Oncology 9.6 (1996): 1259-1265.
Chicago
Yang, Y."Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors". International Journal of Oncology 9, no. 6 (1996): 1259-1265. https://doi.org/10.3892/ijo.9.6.1259