Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port

  • Authors:
    • S Lyass
    • O Lyass
    • A Gabizon
    • T Peretz
    • A Eid
    • M MuggiaSullam
    • A Durst
    • E Shiloni
  • View Affiliations

  • Published online on: December 1, 1996     https://doi.org/10.3892/ijo.9.6.1295
  • Pages: 1295-1299
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Abstract

Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no need for modulation of the chemotherapeutic dose was required. The objective response rate of the whole group was 52.4%. The patients, who had not previously received systemic chemotherapy, had a significantly higher response rate of 81.8% compared to patients treated previously by systemic chemotherapy, who had a response rate of 20% (p=0.0089). In addition, there was a difference in cumulative survival between these two groups. The HAI combined chemotherapy with 5-FU, LV and cisplatin given by bolus injection through an implantable port is effective therapy with similar response rate but considerable reduced toxicity compared to continuous HAI with FUdR. We assume that this therapy might prolong survival significantly especially in patients not treated before by systemic chemotherapy.

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December 1996
Volume 9 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lyass S, Lyass O, Gabizon A, Peretz T, Eid A, MuggiaSullam M, Durst A and Shiloni E: Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port. Int J Oncol 9: 1295-1299, 1996
APA
Lyass, S., Lyass, O., Gabizon, A., Peretz, T., Eid, A., MuggiaSullam, M. ... Shiloni, E. (1996). Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port. International Journal of Oncology, 9, 1295-1299. https://doi.org/10.3892/ijo.9.6.1295
MLA
Lyass, S., Lyass, O., Gabizon, A., Peretz, T., Eid, A., MuggiaSullam, M., Durst, A., Shiloni, E."Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port". International Journal of Oncology 9.6 (1996): 1295-1299.
Chicago
Lyass, S., Lyass, O., Gabizon, A., Peretz, T., Eid, A., MuggiaSullam, M., Durst, A., Shiloni, E."Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port". International Journal of Oncology 9, no. 6 (1996): 1295-1299. https://doi.org/10.3892/ijo.9.6.1295