Open Access

Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®

  • Authors:
    • Hideya Yamazaki
    • Mikio Ogita
    • Kengo Himei
    • Satoaki Nakamura
    • Gen Suzuki
    • Tadayuki Kotsuma
    • Ken Yoshida
    • Yasuo Yoshioka
  • View Affiliations

  • Published online on: July 24, 2017     https://doi.org/10.3892/mco.2017.1339
  • Pages: 336-340
  • Copyright: © Yamazaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to elucidate the effect of intratumoral abscess/necrosis (AN) on the outcome of patients with recurrent head and neck cancer (HNC) treated by stereotactic radiotherapy. The records of 67 patients treated with CyberKnife® in four institutes between August 2000 and July 2010 were reviewed. The frequency of AN appeared to be increased in younger postoperative patients with large ulcerative tumors. The AN+ group exhibited a better initial response rate compared with the AN‑ group (64 vs. 33%, respectively; P=0.04). The 1‑year local control rate was 51 and 75% in the AN+ and AN‑ groups, respectively (P=0.01), while the respective 1-year overall survival rates were 53 and and 71% (P=0.0004). A total of 21 patients (31%) experienced grade ≥3 toxicities, and carotid blowout syndrome (CBOS) was found in 11 patients, resulting in 8 deaths. A significantly larger proportion of patients in the AN+ group developed CBOS (8/18; 44%) compared with the AN‑ group (3/49; 6%) (P=0.001). Therefore, AN may be an important prognostic factor for patients with recurrent HNC, as well as a predictor of lethal toxicity due to CBOS.
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September-2017
Volume 7 Issue 3

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Spandidos Publications style
Yamazaki H, Ogita M, Himei K, Nakamura S, Suzuki G, Kotsuma T, Yoshida K and Yoshioka Y: Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Mol Clin Oncol 7: 336-340, 2017
APA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T. ... Yoshioka, Y. (2017). Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Molecular and Clinical Oncology, 7, 336-340. https://doi.org/10.3892/mco.2017.1339
MLA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7.3 (2017): 336-340.
Chicago
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7, no. 3 (2017): 336-340. https://doi.org/10.3892/mco.2017.1339