Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report
- Authors:
- Tadahiro Shoji
- Ryosuke Takeshita
- Rika Mukaida
- Tamotsu Sato
- Masami Taguchi
- Shunichi Sasou
View Affiliations
Affiliations: Department of Obstetrics and Gynecology, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan, Department of Radiology, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan, Department of Pathology and Laboratory Medicine, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan
- Published online on: July 25, 2017 https://doi.org/10.3892/mco.2017.1347
-
Pages:
407-411
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
A 50‑year‑old woman (gravida 2, para 2) first noticed a small nodule in the right labium majus 2 years prior to the initial visit to the Hachinohe Red Cross Hospital (Hachinohe, Japan), which had gradually increased in size. On physical examination, a well‑circumscribed, elastic, firm, goose egg‑sized, subcutaneous mass protruding from the right labium majus was identified. On magnetic resonance imaging (MRI), the lesion was hypointense on T1‑weighted images and was well‑circumscribed, strongly enhanced and homogeneous on gadolinium‑enhanced images, measuring 7.5x4 cm. The same tumor had measured 2.6 cm on an MRI performed 6 years earlier. Based on the clinical course and imaging findings, angiomyofibroblastoma was diagnosed and surgical resection of the tumor was performed. The tumor was well‑circumscribed and highly vascular. The intraoperative blood loss was 70 ml. Histopathologically, the tumor cells were concentrated around blood vessels, were spindle‑shaped to oval with mild atypia, and were positive for vimentin, desmin, neural cell adhesion molecule (N‑CAM), CD‑34, estrogen receptor and progesterone receptor, and negative for S‑100. Based on these findings, the diagnosis of angiomyofibroblastoma was confirmed. Angiomyofibroblastoma is a benign mesenchymal tumor that occurs in the female external genitalia. Differentiation of this tumor from aggressive angiomyxoma, a fast‑growing infiltrative malignancy that occurs in the same region, may be challenging. The diagnosis of angiomyofibroblastoma is usually based on the histopathological findings of the resected specimen. The present case is of value, as the angiomyofibroblastoma was successfully diagnosed preoperatively based on the clinical course and imaging findings.
View References
1
|
Fletcher CD, Tsang WY, Fisher C, Lee KC
and Chan JK: Angiomyofibroblastoma of the vulva. A benign neoplasm
distinct from aggressive angiomyxoma. Am J Surg Pathol. 16:373–382.
1992. View Article : Google Scholar : PubMed/NCBI
|
2
|
Ding G, Yu Y, Jin M, Xu J and Zhang Z:
Angiomyofibroblastoma-like tumor of the scrotum: A case report and
literature review. Oncol Lett. 7:435–438. 2014.PubMed/NCBI
|
3
|
Ito M, Yamaoka H, Sano K and Hotchi M:
Angiomyofibroblastoma of the male inguinal region. Arch Pathol Lab
Med. 124:1679–1681. 2000.PubMed/NCBI
|
4
|
Laskin WB, Fetsch JF and Tavassoli FA:
Angiomyofibroblastoma of the female genital tract: Analysis of 17
cases including a lipomatous variant. Hum Pathol. 28:1046–1055.
1997. View Article : Google Scholar : PubMed/NCBI
|
5
|
Aono K, Sekine M, Serikawa T, Tojo Y,
Hanaoka J and Takeuchi Y: Two cases of rare vulvar mesenchymal
tumor: Comparisons of aggressive angiomyxoma with
angiomyofibroblastoma. Acta Obst Gynaec Jpn. 50:975–978. 1998.(In
Japanese).
|
6
|
Steeper TA and Rosai J: Aggressive
angiomyxoma of the female pelvis and perineum. Report of nine cases
of distinctive type of gynecologic soft-tissue neoplasm. Am J Surg
Pathol. 7:463–475. 1983. View Article : Google Scholar : PubMed/NCBI
|
7
|
Nagai K, Adachi K and Saito H: Huge
pedunculated angiomyofibroblastoma of vulva. Int J Clin Oncol.
15:201–205. 2010. View Article : Google Scholar : PubMed/NCBI
|
8
|
Qiu P, Wang Z, Li Y and Cui G: Giant
pelvic angiomyofibroblastoma: Case report and literature review.
Diagn Pathol. 9:1062014. View Article : Google Scholar : PubMed/NCBI
|
9
|
Sharon WW Goldkum JR: Enzinger &
Weiss's Soft Tissue Tumors 5th edition. Philadelphia: Mosby
Elsevier; pp. 10872008
|
10
|
Geng J, Hu S and Wang F: Large paravaginal
angiomyofibroblastoma: Magnetic resonance imaging findings. Jpn J
Radiol. 29:152–155. 2011. View Article : Google Scholar : PubMed/NCBI
|
11
|
Quintero C, Sasken H, Houck KL and
Hernandez E: Angiomyofibroblastoma of the retroperitoneum: A case
report. J Reprod Med. 52:741–744. 2007.PubMed/NCBI
|
12
|
Lee CW, Yoon JH, Park DC and Lee SJ:
Aggressive angiomyxoma of the vulva treated by using a
gonadotropin-releasing hormone agonist: A case report. Eur J
Gynaecol Oncol. 32:686–688. 2011.PubMed/NCBI
|
13
|
Palomba S, Oppedisano R, Annunziata G,
Zullo F and Amorosi A: Leuprolide acetate depot plus high-dose
raloxifene hydrochloride before and after surgery for recurrent
vaginal aggressive angiomyxoma: A case report. Gynecol Oncol.
123:172–173. 2011. View Article : Google Scholar : PubMed/NCBI
|
14
|
McCluggage WG, Jamieson T, Dobbs SP and
Grey A: Aggressive angiomyxoma of the vulva: Dramatic response to
gonadotropin-releasing hormone agonist therapy. Gynecol Oncol.
100:623–625. 2006. View Article : Google Scholar : PubMed/NCBI
|
15
|
Fine BA, Munoz AK, Litz CE and Gershenson
DM: Primary medical management of recurrent aggressive angiomyxoma
of the vulva with a gonadotropin-releasing hormone agonist. Gynecol
Oncol. 81:120–122. 2001. View Article : Google Scholar : PubMed/NCBI
|