Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade 3 neoplasia: A retrospective single‑center cohort study

  • Authors:
    • Toshimichi Onuma
    • Kimihisa Tajima
    • Kumiko Sato
    • Katsushige Hattori
    • Shin Fukuda
    • Takahiro Tsuji
    • Yoshio Yoshida
  • View Affiliations

  • Published online on: October 4, 2017     https://doi.org/10.3892/mco.2017.1443
  • Pages:1032-1038
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Abstract

The aim of the present study was to evaluate the clinical significance of atypical squamous cells of undetermined significance (ASC‑US) following cervical conization for cervical intraepithelial neoplasia (CIN) grade 3. This study was a retrospective cohort analysis. The medical records of women treated with conization for CIN 2‑3 were reviewed and 142 patients with CIN 3 who had been diagnosed using the conization specimens were selected. The mean follow‑up period after conization was 41.8 months. Cytological abnormalities after conization were observed in 19.0% of the patients and consisted of ASC‑US (13.4%) and worse than low‑grade squamous intraepithelial lesion (LSIL; 5.6%). Recurrence was defined as a diagnosis worse than CIN 2, and the recurrence rate was 29.6% among patients with abnormal cytology. The recurrence rate was 15.7% in the ASC‑US group and 71.4% in the worse than LSIL group. There was no significant difference in the time of initial identification of abnormal cytology after treatment between the worse than LSIL and the ASC‑US groups (P=0.054). However, the ASC‑US group had a significantly better cumulative recurrence‑free rate compared with the worse than LSIL group (P<0.05). Women with ASC‑US following treatment for CIN appear to be at a relatively high risk. Regarding the risk stratification of women following treatment for CIN, if surveillance cytology shows ASC‑US, immediate colposcopy is recommended, along with long‑term follow‑up.

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December 2017
Volume 7 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Onuma, T., Tajima, K., Sato, K., Hattori, K., Fukuda, S., Tsuji, T., & Yoshida, Y. (2017). Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade 3 neoplasia: A retrospective single‑center cohort study. Molecular and Clinical Oncology, 7, 1032-1038. https://doi.org/10.3892/mco.2017.1443
MLA
Onuma, T., Tajima, K., Sato, K., Hattori, K., Fukuda, S., Tsuji, T., Yoshida, Y."Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade 3 neoplasia: A retrospective single‑center cohort study". Molecular and Clinical Oncology 7.6 (2017): 1032-1038.
Chicago
Onuma, T., Tajima, K., Sato, K., Hattori, K., Fukuda, S., Tsuji, T., Yoshida, Y."Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade 3 neoplasia: A retrospective single‑center cohort study". Molecular and Clinical Oncology 7, no. 6 (2017): 1032-1038. https://doi.org/10.3892/mco.2017.1443