Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report

  • Authors:
    • Jieyun Xia
    • Haiying Sun
    • Zhiling Yan
    • Feng Zhu
    • Kai Zhao
    • Kailin Xu
  • View Affiliations

  • Published online on: June 25, 2018     https://doi.org/10.3892/mco.2018.1661
  • Pages: 297-301
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Abstract

Philadelphia chromosome (Ph)‑positive acute lymphoblastic leukemia (ALL) complicated by bone marrow necrosis (BMN) and acute renal insufficiency (ARI) is rare in clinical practice. The aim of the present study was to summarize the clinical characteristics and treatment methods of a case of Ph+ ALL complicated by BMN and ARI. A 23‑year‑old male patient presented with pyrexia and a 2‑month history of bone pain, and was diagnosed with Ph+ ALL complicated with BMN and ARI on peripheral blood tests, blood biochemistry tests, BM smear and fluorescence in situ hybridization. The patient underwent repeated hemodialysis, imatinib combination and maintenance chemotherapy, followed by allogeneic hematopoietic stem‑cell transplantation. Some of the clinical signs and symptoms were alleviated, whereas others disappeared, and renal function was restored to normal. BM aspiration confirmed absence of necrosis and null lymphoblasts. Therefore, timely accurate diagnosis and effective treatment are crucial for patients with Ph+ ALL exhibiting potentially fatal complications.
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September-2018
Volume 9 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Xia J, Sun H, Yan Z, Zhu F, Zhao K and Xu K: Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Mol Clin Oncol 9: 297-301, 2018
APA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., & Xu, K. (2018). Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Molecular and Clinical Oncology, 9, 297-301. https://doi.org/10.3892/mco.2018.1661
MLA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9.3 (2018): 297-301.
Chicago
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9, no. 3 (2018): 297-301. https://doi.org/10.3892/mco.2018.1661