In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches

  • Authors:
    • Hao Chen
    • Hai‑Wei Yang
    • Ji‑Fu Wei
    • Ai‑Lin Tao
  • View Affiliations

  • Published online on: July 21, 2014     https://doi.org/10.3892/mmr.2014.2399
  • Pages: 2130-2136
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Per a 6 and Bla g 6 are cockroach allergens found in Periplaneta americana and Blattella germanica, respectively. The objective of the present study was to predict the B‑ and T‑cell epitopes of the Per a 6 and Bla g 6 allergens. Three immunoinformatics tools, the DNAStar Protean system, the Bioinformatics Predicted Antigenic Peptides system and the BepiPred 1.0 server, were used to predict the potential B‑cell epitopes, while Net‑MHCIIpan‑2.0 and NetMHCII‑2.2 were used to predict the T‑cell epitopes of the two allergens. As a result, seven peptides were predicted in the Per a 6 allergen and seven peptides were predicted in the Bla g 6 allergen in the B‑cell epitope predictions. In the T‑cell prediction, the Per a 6 allergen was predicted to have nine strongly binding nonamer core epitope sequences (IC50<50 nm) and 28 weakly binding sequences (50 nm
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 10 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Yang HW, Wei JF and Tao AL: In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches. Mol Med Rep 10: 2130-2136, 2014
APA
Chen, H., Yang, H., Wei, J., & Tao, A. (2014). In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches. Molecular Medicine Reports, 10, 2130-2136. https://doi.org/10.3892/mmr.2014.2399
MLA
Chen, H., Yang, H., Wei, J., Tao, A."In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches". Molecular Medicine Reports 10.4 (2014): 2130-2136.
Chicago
Chen, H., Yang, H., Wei, J., Tao, A."In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches". Molecular Medicine Reports 10, no. 4 (2014): 2130-2136. https://doi.org/10.3892/mmr.2014.2399