MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells

  • Authors:
    • Liang Zhu
    • Rong Liu
    • Wei Zhang
    • Sheng Qian
    • Jian‑Hua Wang
  • View Affiliations

  • Published online on: June 25, 2015     https://doi.org/10.3892/mmr.2015.3998
  • Pages: 4652-4656
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Abstract

Ubiquitin specific peptidase 7 (UPS7) has a critical role in the development and progression of cancer, at least in part, through its regulation of p53 protein stability. However, its molecular determinants remain to be elucidated. In the present study, it was identified that microRNA‑205 (miR‑205) may negatively regulate UPS7 protein levels through targeting its 3'‑untranslated region in hepatocellular carcinoma (HCC) cells. As a result, miR‑205 mimics inhibited USP7 protein levels while antisense miR‑205 enhanced USP7 protein levels, thereby modulating the p53 signaling pathway and cell proliferation levels. In conclusion, the data presents a novel molecule for the dysregulated expression of USP7 in HCC, which may assist in elucidating mechanisms underlying the tumorigenesis of HCC.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu L, Liu R, Zhang W, Qian S and Wang JH: MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells. Mol Med Rep 12: 4652-4656, 2015
APA
Zhu, L., Liu, R., Zhang, W., Qian, S., & Wang, J. (2015). MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells. Molecular Medicine Reports, 12, 4652-4656. https://doi.org/10.3892/mmr.2015.3998
MLA
Zhu, L., Liu, R., Zhang, W., Qian, S., Wang, J."MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells". Molecular Medicine Reports 12.3 (2015): 4652-4656.
Chicago
Zhu, L., Liu, R., Zhang, W., Qian, S., Wang, J."MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells". Molecular Medicine Reports 12, no. 3 (2015): 4652-4656. https://doi.org/10.3892/mmr.2015.3998