Open Access

Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection

  • Authors:
    • Jun Tao
    • Xiao Yang
    • Pengchao Li
    • Jifu Wei
    • Xiaheng Deng
    • Yidong Cheng
    • Chao Qin
    • Xiaobing Ju
    • Xiaoxin Meng
    • Jie Li
    • Min Gu
    • Qiang Lu
    • Changjun Yin
  • View Affiliations

  • Published online on: August 27, 2015     https://doi.org/10.3892/mmr.2015.4257
  • Pages: 6752-6760
  • Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. However, the significance of circulating miRNAs in upper tract urothelial carcinoma (UTUC) has remained to be investigated. The present study performed a genome‑wide serum miRNA analysis using a deep sequencing platform for initial screening. Subsequently, serum samples of 46 UTUC patients and 30 cancer‑free individuals with hematuria were subjected to a quantitative reverse‑transcription polymerase chain reaction analysis. The expression of thirteen miRNAs (miR‑664a‑3p, miR‑423‑5p, miR‑431‑5p, miR‑191‑5p, miR‑92a‑3p, miR‑22‑3p, miR‑26a‑5p, miR‑33b‑3p, miR‑16‑5p, let‑7a‑5p, let‑7b‑5p, let‑7f‑5p and let‑7c) was significantly different in serum from UTUC patients compared with that in control samples. Receiver operator characteristic analysis showed that 10 miRNAs (miR‑664a‑3p, miR‑431‑5p, miR‑423‑5p, miR‑191‑5p, miR‑33b‑3p, miR‑26a‑5p, miR‑22‑3p, miR‑16‑5p, let‑7b‑5p and let‑7c) had the potential to distinguish individuals with UTUC from the controls (areas under the curve >0.8). The present study provided the first evidence for the potential use of circulating miRNAs as biomarkers for UTUC diagnosis, which remains to be verified by further studies.
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November-2015
Volume 12 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Tao J, Yang X, Li P, Wei J, Deng X, Cheng Y, Qin C, Ju X, Meng X, Li J, Li J, et al: Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. Mol Med Rep 12: 6752-6760, 2015
APA
Tao, J., Yang, X., Li, P., Wei, J., Deng, X., Cheng, Y. ... Yin, C. (2015). Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. Molecular Medicine Reports, 12, 6752-6760. https://doi.org/10.3892/mmr.2015.4257
MLA
Tao, J., Yang, X., Li, P., Wei, J., Deng, X., Cheng, Y., Qin, C., Ju, X., Meng, X., Li, J., Gu, M., Lu, Q., Yin, C."Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection". Molecular Medicine Reports 12.5 (2015): 6752-6760.
Chicago
Tao, J., Yang, X., Li, P., Wei, J., Deng, X., Cheng, Y., Qin, C., Ju, X., Meng, X., Li, J., Gu, M., Lu, Q., Yin, C."Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection". Molecular Medicine Reports 12, no. 5 (2015): 6752-6760. https://doi.org/10.3892/mmr.2015.4257