Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling

  • Authors:
    • Changxing Wang
    • Weidong Wang
    • Xiaping Jin
    • Jianguo Shen
    • Weifeng Hu
    • Tao Jiang
  • View Affiliations

  • Published online on: June 2, 2016     https://doi.org/10.3892/mmr.2016.5357
  • Pages: 1365-1370
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Abstract

Puerarin is an important active ingredient in the root of kudzu vine due to its pharmacological properties. The aim of the present study is to contribute to the existing knowledge of the effect of puerarin in the attenuation of inflammation and oxidation in mice with collagen antibody-induced arthritis via toll‑like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling. Arthritis was induced using injection of anti‑type II collagen antibodies. Treatment with puerarin was observed to significantly decrease clinical scoring of the collagen antibody‑induced arthritis and suppress oxidative stress and the inflammatory response in mice. Furthermore, puerarin was demonstrated to inhibit mRNA expression of matrix metalloproteinase‑9 and protein expression of TLR4 following collagen antibody-induced arthritis in mice. The effect of puerarin may be associated with the suppression of NF‑κB activity in collagen antibody‑induced arthritis mice. Furthermore, upregulation of phosphorylated (p)‑Janus kinase 2 and p‑signal transducer and activator of transcription 3 protein expression was suppressed by puerarin. The results of the present study indicate, for the first time, the effect of puerarin to attenuate inflammation and oxidation in mice with collagen antibody‑induced arthritis via TLR4/NF-κB signaling.
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August-2016
Volume 14 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang C, Wang W, Jin X, Shen J, Hu W and Jiang T: Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling. Mol Med Rep 14: 1365-1370, 2016
APA
Wang, C., Wang, W., Jin, X., Shen, J., Hu, W., & Jiang, T. (2016). Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling. Molecular Medicine Reports, 14, 1365-1370. https://doi.org/10.3892/mmr.2016.5357
MLA
Wang, C., Wang, W., Jin, X., Shen, J., Hu, W., Jiang, T."Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling". Molecular Medicine Reports 14.2 (2016): 1365-1370.
Chicago
Wang, C., Wang, W., Jin, X., Shen, J., Hu, W., Jiang, T."Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling". Molecular Medicine Reports 14, no. 2 (2016): 1365-1370. https://doi.org/10.3892/mmr.2016.5357