Open Access

Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus

  • Authors:
    • Jin‑A Park
    • Joon Ha Park
    • Ji Hyeon Ahn
    • Jong‑Dai Kim
    • Moo‑Ho Won
    • Choong‑Hyun Lee
  • View Affiliations

  • Published online on: August 9, 2016     https://doi.org/10.3892/mmr.2016.5619
  • Pages: 3215-3219
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Antioxidant-like protein-1 (AOP-1) reduces the intracellular level of reactive oxygen species. In the present study, the age‑related change in AOP‑1 expression in the hippocampus among young, adult and aged gerbils was compared using western blot analysis and immunohistochemistry. The results demonstrated that the protein expression of AOP‑1 was gradually and significantly increased in the hippocampus during the normal aging process. In addition, the age‑dependent increase in AOP‑1 immunoreactivity was also observed in pyramidal neurons of the hippocampus proper; however, in the dentate gyrus, AOP‑1 immunoreactivity was not altered during the normal aging process. These results indicated that the expression of AOP‑1 is significantly increased in the hippocampus proper, but not in the dentate gyrus, during the normal aging process.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Park JA, Park JH, Ahn JH, Kim JD, Won MH and Lee CH: Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus. Mol Med Rep 14: 3215-3219, 2016
APA
Park, J., Park, J.H., Ahn, J.H., Kim, J., Won, M., & Lee, C. (2016). Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus. Molecular Medicine Reports, 14, 3215-3219. https://doi.org/10.3892/mmr.2016.5619
MLA
Park, J., Park, J. H., Ahn, J. H., Kim, J., Won, M., Lee, C."Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus". Molecular Medicine Reports 14.4 (2016): 3215-3219.
Chicago
Park, J., Park, J. H., Ahn, J. H., Kim, J., Won, M., Lee, C."Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus". Molecular Medicine Reports 14, no. 4 (2016): 3215-3219. https://doi.org/10.3892/mmr.2016.5619