Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway

  • Authors:
    • Hongbing Gu
    • Runbi Ji
    • Xu Zhang
    • Mei Wang
    • Wei Zhu
    • Hui Qian
    • Yongchang Chen
    • Pengcheng Jiang
    • Wenrong Xu
  • View Affiliations

  • Published online on: August 11, 2016     https://doi.org/10.3892/mmr.2016.5625
  • Pages: 3452-3458
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Abstract

Mesenchymal stem cells (MSCs) are a component of the tumor microenvironment and can promote the development of gastric cancer through paracrine mechanism. However, the effects of MSC‑exosomes (MSC‑ex) on gastric cancer are less clear. The present study reported that MSC‑ex promoted the proliferative and metastatic potential of gastric cancer cells ex vivo. It was found that MSC‑ex enhanced the migration and invasion of HGC‑27 cells via the induction of the epithelial‑mesenchymal transition. MSC‑ex increased the expression of mesenchymal markers and reduced the expression of epithelial markers in gastric cancer cells. MSC‑ex also enhanced the tumorigenicity of gastric cancer cells ex vivo. MSC‑ex induced the stemness of gastric cancer cells. The expression of octamer‑binding transcription factor 4, ex determining region Y‑box 2 and Lin28B significantly increased in gastric cancer cells treated with MSC‑ex. The present study further demonstrated that MSC‑ex elicited these biological effects predominantly via the activation of the protein kinase B signaling pathway. Taken together, the present findings provided novel evidence for the role of MSC‑ex in gastric cancer and a new opportunity for improving the efficiency of gastric cancer treatment by targeting MSC‑ex.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gu H, Ji R, Zhang X, Wang M, Zhu W, Qian H, Chen Y, Jiang P and Xu W: Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway. Mol Med Rep 14: 3452-3458, 2016
APA
Gu, H., Ji, R., Zhang, X., Wang, M., Zhu, W., Qian, H. ... Xu, W. (2016). Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway. Molecular Medicine Reports, 14, 3452-3458. https://doi.org/10.3892/mmr.2016.5625
MLA
Gu, H., Ji, R., Zhang, X., Wang, M., Zhu, W., Qian, H., Chen, Y., Jiang, P., Xu, W."Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway". Molecular Medicine Reports 14.4 (2016): 3452-3458.
Chicago
Gu, H., Ji, R., Zhang, X., Wang, M., Zhu, W., Qian, H., Chen, Y., Jiang, P., Xu, W."Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway". Molecular Medicine Reports 14, no. 4 (2016): 3452-3458. https://doi.org/10.3892/mmr.2016.5625