Open Access

Antiviral activities of atractylon from Atractylodis Rhizoma

  • Authors:
    • Yang Cheng
    • Jing‑Yin Mai
    • Tian‑Lu Hou
    • Jian Ping
    • Jian‑Jie Chen
  • View Affiliations

  • Published online on: September 5, 2016     https://doi.org/10.3892/mmr.2016.5713
  • Pages: 3704-3710
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Atractylodis Rhizoma is a traditional medicinal herb, which has antibacterial, antiviral, anti‑inflammatory and anti‑allergic, anticancer, gastroprotective and neuroprotective activities. It is widely used for treating fever, cold, phlegm, edema and arthralgia syndrome in South‑East Asian nations. In this study, 6 chemical compositions of Atractylodis Rhizoma were characterized by spectral analysis and their antiviral activities were evaluated in vitro and in vivo. Among them, atractylon showed most significant antiviral activities. Atractylon treatment at doses of 10‑40 mg/kg for 5 days attenuated influenza A virus (IAV)‑induced pulmonary injury and decreased the serum levels of interleukin (IL)‑6, tumor necrosis factor‑α and IL‑1β, but increased interferon‑β (IFN‑β) levels. Atractylon treatment upregulated the expression of Τoll‑like receptor 7 (TLR7), MyD88, tumor necrosis factor receptor‑associated factor 6 and IFN‑β mRNA but downregulated nuclear factor‑κB p65 protein expression in the lung tissues of IAV‑infected mice. These results demonstrated that atractylon significantly alleviated IAV‑induced lung injury via regulating the TLR7 signaling pathway, and may warrant further evaluation as a possible agent for IAV treatment.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Mai JY, Hou TL, Ping J and Chen JJ: Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep 14: 3704-3710, 2016
APA
Cheng, Y., Mai, J., Hou, T., Ping, J., & Chen, J. (2016). Antiviral activities of atractylon from Atractylodis Rhizoma. Molecular Medicine Reports, 14, 3704-3710. https://doi.org/10.3892/mmr.2016.5713
MLA
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14.4 (2016): 3704-3710.
Chicago
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14, no. 4 (2016): 3704-3710. https://doi.org/10.3892/mmr.2016.5713