Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory

  • Authors:
    • Dae Young Yoo
    • Hyo Young Jung
    • Jong Whi Kim
    • Hee Sun Yim
    • Dae Won Kim
    • Hajin Nam
    • Jun Gyo Suh
    • Jung Hoon Choi
    • Moo‑Ho Won
    • Yeo Sung Yoon
    • In Koo Hwang
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/mmr.2016.5804
  • Pages: 4755-4760
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Dynamin 1 is a known synaptic protein, which has is key in the presynaptic regulation of endocytosis. The present study investigated the association between age and the observed changes in Morris water maze performance, and immunoreactivity and protein levels of dynamin 1 in the mouse hippocampal formation. In addition, the effects of dynasore, an inhibitor of dynamin 1, on the hippocampal dependent memory were determined to elucidate the correlation between dynamin 1 and memory. In the training phase of the Morris water maze task, the mean escape latency of the aged group (24 months old) was significantly longer, compared with that of the adult group (4 months old), although the average swimming speed and the total distance traveled during the probe trial were similar in the two groups. In the aged group, the time spent locating the target platform was significantly longer and the time spent in the correct quadrant was significantly shorter, compared with those in the adult group. In the adult group, a moderate level of dynamin 1 was detected in the hippocampal CA1 and CA3 regions, and in the dentate gyrus. In the aged group, the immunoreactivity of dynamin 1 was almost eliminated in the CA3 region and the dentate gyrus. In addition, the protein levels of dynamin 1 in the brain were significantly lower in the aged group, compared with those in the adult group. The direct infusion of dynasore, significantly reduced the contextual memory, compared with that of animals in the vehicle‑treated group. These results suggested that dynamin 1 was susceptible to the aging process, and that a reduction in dynamin 1 may result in hippocampal‑dependent memory deficits by disrupting endocytosis and the release of neurotransmitters.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 14 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yoo DY, Jung HY, Kim JW, Yim HS, Kim DW, Nam H, Suh JG, Choi JH, Won MH, Yoon YS, Yoon YS, et al: Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory. Mol Med Rep 14: 4755-4760, 2016
APA
Yoo, D.Y., Jung, H.Y., Kim, J.W., Yim, H.S., Kim, D.W., Nam, H. ... Hwang, I.K. (2016). Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory. Molecular Medicine Reports, 14, 4755-4760. https://doi.org/10.3892/mmr.2016.5804
MLA
Yoo, D. Y., Jung, H. Y., Kim, J. W., Yim, H. S., Kim, D. W., Nam, H., Suh, J. G., Choi, J. H., Won, M., Yoon, Y. S., Hwang, I. K."Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory". Molecular Medicine Reports 14.5 (2016): 4755-4760.
Chicago
Yoo, D. Y., Jung, H. Y., Kim, J. W., Yim, H. S., Kim, D. W., Nam, H., Suh, J. G., Choi, J. H., Won, M., Yoon, Y. S., Hwang, I. K."Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory". Molecular Medicine Reports 14, no. 5 (2016): 4755-4760. https://doi.org/10.3892/mmr.2016.5804