Post-translational modifications of FOXO family proteins (Review)

  • Authors:
    • Ziyao Wang
    • Tinghe Yu
    • Ping Huang
  • View Affiliations

  • Published online on: October 20, 2016     https://doi.org/10.3892/mmr.2016.5867
  • Pages: 4931-4941
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Abstract

The Forkhead box O (FOXO) protein family is predominantly involved in apoptosis, oxidative stress, DNA damage/repair, tumor angiogenesis, glycometabolism, regulating life span and other important biological processes. Its activity is affected by a variety of posttranslational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. When cells are subjected to different environments, the corresponding PTMs act on the FOXO protein family, to change transcriptional activity or subcellular localization, and the expression of downstream target genes, will ultimately affect the biological behavior of the cells. In this review, we will discuss the biological characteristics of FOXO protein PTMs.
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December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Z, Yu T and Huang P: Post-translational modifications of FOXO family proteins (Review). Mol Med Rep 14: 4931-4941, 2016
APA
Wang, Z., Yu, T., & Huang, P. (2016). Post-translational modifications of FOXO family proteins (Review). Molecular Medicine Reports, 14, 4931-4941. https://doi.org/10.3892/mmr.2016.5867
MLA
Wang, Z., Yu, T., Huang, P."Post-translational modifications of FOXO family proteins (Review)". Molecular Medicine Reports 14.6 (2016): 4931-4941.
Chicago
Wang, Z., Yu, T., Huang, P."Post-translational modifications of FOXO family proteins (Review)". Molecular Medicine Reports 14, no. 6 (2016): 4931-4941. https://doi.org/10.3892/mmr.2016.5867