Open Access

Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection

  • Authors:
    • In Seung Jang
    • Sun Joo Park
  • View Affiliations

  • Published online on: November 16, 2016     https://doi.org/10.3892/mmr.2016.5949
  • Pages: 5489-5494
  • Copyright: © Jang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The human immunodeficiency virus (HIV) is a lentivirus that results in acquired immunodeficiency syndrome (AIDS). HIV treatment involving chemical therapeutic agents has improved the quality of life of HIV/AIDS patients. The present study demonstrates that a hydroxyproline-containing marine collagen peptide (APHCP) derived from Alaska pollack inhibits HIV‑1 infection in the MT-4 human T cell‑line. APHCP inhibited HIV-1IIIB-induced cell lysis, syncytia formation, reverse transcriptase activity and viral p24 production at non‑cytotoxic concentrations; however, APHCP did not inhibit HIV‑2ROD infection in MT‑4 cells. This suggests that the anti‑HIV activity of APHCP is specific to HIV‑1. In addition, substitution of hydroxyproline residues in APHCP with prolines impaired its anti‑HIV‑1 activity, suggesting that the hydroxyl group of hydroxyprolines is required for the anti‑HIV‑1 activity of APHCP. These results suggested that the marine peptide APHCP may be a novel drug candidate in the development of next‑generation therapeutic agents for the treatment of HIV/AIDS.
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December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jang IS and Jang IS: Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection. Mol Med Rep 14: 5489-5494, 2016
APA
Jang, I.S., & Jang, I.S. (2016). Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection. Molecular Medicine Reports, 14, 5489-5494. https://doi.org/10.3892/mmr.2016.5949
MLA
Jang, I. S., Park, S. J."Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection". Molecular Medicine Reports 14.6 (2016): 5489-5494.
Chicago
Jang, I. S., Park, S. J."Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection". Molecular Medicine Reports 14, no. 6 (2016): 5489-5494. https://doi.org/10.3892/mmr.2016.5949