Open Access

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release

  • Authors:
    • Qiong Wang
    • Jun Wang
    • Junfang Wang
    • Shanchao Hong
    • Feifei Han
    • Jingyu Chen
    • Guoqian Chen
  • View Affiliations

  • Published online on: March 23, 2017     https://doi.org/10.3892/mmr.2017.6364
  • Pages: 3062-3068
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The proinflammatory factor high‑mobility group box protein 1 (HMGB1) has been implicated in the pathogenesis of lung fibrosis; however, the role of HMGB1 in lung fibrosis remains unclear. It has previously been reported that nuclear factor (NF)‑κB and transforming growth factor (TGF)‑β1 may be involved in lung fibrosis. Therefore, the present study aimed to examine the potential molecular mechanisms that underlie HMGB1‑induced lung fibrosis via the regulation of NF‑κB and TGF‑β1. The results demonstrated that HMGB1 stimulation increased the activation of NF‑κB and the release of TGF‑β1, as well as the expression of α‑smooth muscle actin (α‑SMA) and collagen I in human lung fibroblasts in vitro. In addition, inhibition of NF‑κB activation blocked HMGB1‑induced TGF‑β1 release, as well as α‑SMA and collagen I expression in lung fibroblasts. Preventing the release of TGF‑β1 inhibited HMGB1‑induced α‑SMA and collagen I expression; however, it had no effect on NF‑κB activation. Collectively, these findings indicate that HMGB1 induces fibroblast to myofibroblast differentiation of lung fibroblasts via NF‑κB‑mediated TGF‑β1 release.
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May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Q, Wang J, Wang J, Hong S, Han F, Chen J and Chen G: HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release. Mol Med Rep 15: 3062-3068, 2017
APA
Wang, Q., Wang, J., Wang, J., Hong, S., Han, F., Chen, J., & Chen, G. (2017). HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release. Molecular Medicine Reports, 15, 3062-3068. https://doi.org/10.3892/mmr.2017.6364
MLA
Wang, Q., Wang, J., Wang, J., Hong, S., Han, F., Chen, J., Chen, G."HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release". Molecular Medicine Reports 15.5 (2017): 3062-3068.
Chicago
Wang, Q., Wang, J., Wang, J., Hong, S., Han, F., Chen, J., Chen, G."HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release". Molecular Medicine Reports 15, no. 5 (2017): 3062-3068. https://doi.org/10.3892/mmr.2017.6364