Open Access

Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus

  • Authors:
    • Joon Ha Park
    • Jin‑A Park
    • Ji Hyeon Ahn
    • Yang Hee Kim
    • Il Jun Kang
    • Moo‑Ho Won
    • Choong‑Hyun Lee
  • View Affiliations

  • Published online on: May 31, 2017     https://doi.org/10.3892/mmr.2017.6671
  • Pages: 661-665
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Albumin, the most abundant plasma protein, is known to exhibit a neuroprotective effect in animal models of focal and global cerebral ischemia. In the present study, the expression and immunoreactivity of albumin was examined in the hippocampus following 5 min of transient cerebral ischemia in gerbils. Albumin immunoreactivity was observed in microglia of the CA1 hippocampal region 2 days post‑ischemic insult, and it was significantly increased at 4 days following ischemia-reperfusion. In addition, at 4 days post‑ischemic insult, albumin‑immunoreactive microglia were abundant in the stratum pyramidale of the CA1 region. The present results demonstrated that albumin was newly expressed post‑injury in microglia in the CA1 region, suggesting ischemia‑induced neuronal loss. Albumin expression may therefore be associated with ischemia‑induced delayed neuronal death in the CA1 region following transient cerebral ischemia.
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July-2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Park JH, Park JA, Ahn JH, Kim YH, Kang IJ, Won MH and Lee CH: Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Mol Med Rep 16: 661-665, 2017
APA
Park, J.H., Park, J., Ahn, J.H., Kim, Y.H., Kang, I.J., Won, M., & Lee, C. (2017). Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Molecular Medicine Reports, 16, 661-665. https://doi.org/10.3892/mmr.2017.6671
MLA
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16.1 (2017): 661-665.
Chicago
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16, no. 1 (2017): 661-665. https://doi.org/10.3892/mmr.2017.6671