Open Access

Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice

Corrigendum in: /10.3892/mmr.2017.7698

  • Authors:
    • Jianshu Gao
    • Xiaoqiang Liu
    • Bingjian Wang
    • Haiyan Xu
    • Qiang Xia
    • Tianfei Lu
    • Fang Wang
  • View Affiliations

  • Published online on: May 29, 2017     https://doi.org/10.3892/mmr.2017.6643
  • Pages: 673-679
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The farnesoid X receptor (FXR) is implicated in cholesterol and bile acid homeostasis; however, its role following myocardial infarction (MI) has yet to be elucidated. The aim of the present study was to investigate the effects of FXR knockout on left ventricular (LV) remodeling following MI. Coronary arteries of wild type (WT) and FXR‑/‑ mice were permanently occluded to cause MI, and serial echocardiographic and histological tests were conducted. At 4 weeks post‑MI, FXR‑/‑ mice exhibited significantly smaller infarct sizes (34.20±2.58 vs. 44.20±3.19%), improved ejection fraction (47.31±1.08 vs. 37.64±0.75%) and reduced LV chamber dilation compared with WT mice. LV remodeling was significant as early as 7 days post‑MI in FXR‑/‑ compared with WT mice. Histological features associated with enhanced long‑term remodeling and improved functionality, such as increased angiogenesis via detection of CD31 and reduced fibrosis, were observed in the FXR‑/‑ group. Myocyte apoptosis within the infarcted zones appeared significantly reduced by day 7 in FXR‑/‑ mice. In conclusion, the results of the present study suggested that FXR knockout may participate in the preservation of post‑MI cardiac functionality, via reducing fibrosis and chronic apoptosis, and ameliorating ventricular function.
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July-2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gao J, Liu X, Wang B, Xu H, Xia Q, Lu T and Wang F: Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Mol Med Rep 16: 673-679, 2017
APA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., & Wang, F. (2017). Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Molecular Medicine Reports, 16, 673-679. https://doi.org/10.3892/mmr.2017.6643
MLA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16.1 (2017): 673-679.
Chicago
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16, no. 1 (2017): 673-679. https://doi.org/10.3892/mmr.2017.6643