Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response

  • Authors:
    • Chunhua Wang
    • Zongyao Hao
    • Jun Zhou
    • Li Zhang
    • Yexiang Sun
    • Chaozhao Liang
  • View Affiliations

  • Published online on: May 25, 2017     https://doi.org/10.3892/mmr.2017.6631
  • Pages: 922-928
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Abstract

In the present study, the protective effect and the potential underlying mechanism of rutaecarpine (Ru) on renal ischemia reperfusion injury (IRI) in rats were investigated. A renal ischemia reperfusion mouse model was established. Ru at 30, 60 mg/kg administered intraperitoneally prior to reperfusion led to attenuated renal injury. The results demonstrated that Ru treatment significantly reduced the content of serum creatinine, urea nitrogen and neutrophil gelatinase‑associated lipocalin in rats with renal IRI. In addition, Ru treatment improved the degree of renal proximal tubular necrosis, decreased the content of inflammatory cytokines in reperfused renal tissue and increased serum superoxide dismutase levels to protect the kidney. The associated underlying mechanism may involve the inhibition of p38 kinase phosphorylation and c‑Jun N‑terminal kinase, anti‑lipid peroxidation, elimination of free radicals, and a reduction in the degree of apoptotic damage and oxidative stress injury induced by renal IRI. Therefore, Ru may be a suitable compound for the prevention and treatment of renal IRI.
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July-2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang C, Hao Z, Zhou J, Zhang L, Sun Y and Liang C: Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response. Mol Med Rep 16: 922-928, 2017
APA
Wang, C., Hao, Z., Zhou, J., Zhang, L., Sun, Y., & Liang, C. (2017). Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response. Molecular Medicine Reports, 16, 922-928. https://doi.org/10.3892/mmr.2017.6631
MLA
Wang, C., Hao, Z., Zhou, J., Zhang, L., Sun, Y., Liang, C."Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response". Molecular Medicine Reports 16.1 (2017): 922-928.
Chicago
Wang, C., Hao, Z., Zhou, J., Zhang, L., Sun, Y., Liang, C."Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response". Molecular Medicine Reports 16, no. 1 (2017): 922-928. https://doi.org/10.3892/mmr.2017.6631