Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats

  • Authors:
    • Bayixiati Qianman
    • Ayidaer Jialihasi
    • Batiza Asilehan
    • Aliya Kubai
    • Rakimbaiev Aibek
    • Aikeremu Wupuer
    • Wulanbai Tangkejie
    • Abudouheilil Maimaitiaili
    • Nuerai Shawutali
    • Aynaz Badelhan
    • Adili Aizezi
    • Amuding Aisaiding
    • Jianati Wuerliebieke
    • Yerzat Bakyt
    • Elihaer Makemutibieke
    • Jiasharete Jielile
  • View Affiliations

  • Published online on: June 29, 2017     https://doi.org/10.3892/mmr.2017.6889
  • Pages: 2355-2360
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Abstract

Collapsin response mediator protein-2 (CRMP-2) is involved in neurite elongation and regeneration; however, its role in wound healing remains to be elucidated. The present study aimed to investigate the effects of active mobilization treatment on Achilles tendon healing and to determine the role of CRMP‑2 in the healing process. Sprague Dawley rats were subjected to Achilles tendon injury, which was verified by hematoxylin and eosin staining and scanning electronic microscopy. Immobilization induced the disruption of collagen fibril arrangement and promoted collagen fibril damage. The average collagen fibril perimeter in the active mobilization group was significantly increased compared with in the immobilization group (125.6±0.8 nm vs. 119.9±1.7 nm; P<0.05). In addition, immunohistological analysis revealed that CRMP‑2 expression was significantly upregulated, particularly in the ruptured site of Achilles tendon tissues derived from animals in the mobilization group compared with the immobilization group (0.32±0.00 vs. 0.08±0.00; P<0.05). The increased CRMP‑2 levels were also confirmed by western blotting (active mobilization group, 0.71±0.03; immobilization group, 0.49±0.01 nm; P<0.05). These results indicated that active mobilization may promote Achilles tendon healing via upregulation of CRMP‑2 protein expression.
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September-2017
Volume 16 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Qianman B, Jialihasi A, Asilehan B, Kubai A, Aibek R, Wupuer A, Tangkejie W, Maimaitiaili A, Shawutali N, Badelhan A, Badelhan A, et al: Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats. Mol Med Rep 16: 2355-2360, 2017
APA
Qianman, B., Jialihasi, A., Asilehan, B., Kubai, A., Aibek, R., Wupuer, A. ... Jielile, J. (2017). Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats. Molecular Medicine Reports, 16, 2355-2360. https://doi.org/10.3892/mmr.2017.6889
MLA
Qianman, B., Jialihasi, A., Asilehan, B., Kubai, A., Aibek, R., Wupuer, A., Tangkejie, W., Maimaitiaili, A., Shawutali, N., Badelhan, A., Aizezi, A., Aisaiding, A., Wuerliebieke, J., Bakyt, Y., Makemutibieke, E., Jielile, J."Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats". Molecular Medicine Reports 16.3 (2017): 2355-2360.
Chicago
Qianman, B., Jialihasi, A., Asilehan, B., Kubai, A., Aibek, R., Wupuer, A., Tangkejie, W., Maimaitiaili, A., Shawutali, N., Badelhan, A., Aizezi, A., Aisaiding, A., Wuerliebieke, J., Bakyt, Y., Makemutibieke, E., Jielile, J."Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats". Molecular Medicine Reports 16, no. 3 (2017): 2355-2360. https://doi.org/10.3892/mmr.2017.6889