Open Access

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms

  • Authors:
    • Mu Zhu
    • Zhongyang Liu
    • Mingze Gao
    • Yan Zhang
    • Yuheng Li
    • Shukuan Ling
    • Pengfei Zhang
    • Chenyang Zhao
    • Lijun Jiang
    • Yu Liu
    • Qi Li
    • Dong Li
    • Sumin Hu
    • Yingxian Li
  • View Affiliations

  • Published online on: August 18, 2017     https://doi.org/10.3892/mmr.2017.7287
  • Pages: 5165-5174
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Microgravity has been previously demonstrated to induce skeletal muscle atrophy, loss of muscle force and disorders in myogenesis and metabolism. Current pharmacological strategies exhibit poor efficacy. Bu Zhong Yi Qi decoction (BZ) is a well‑known traditional Chinese medicine decoction used for myasthenia gravis. In the present study, its effect on unloading induced muscle atrophy was investigated. The mousetail suspension model was used to simulate weightlessness induced muscle atrophy. The results indicated that BZ could significantly protect muscles from simulated weightlessness‑induced atrophy. To elucidate the underlying mechanisms, drugCIPHER‑CS methods were introduced to predict its potential targets, significantly enriched pathways and biological processes. The results demonstrated that the calcium signaling pathway, citrate cycle, biosynthetic and lipid metabolic process are affected by BZ. Among the targets, nuclear receptor corepressor 1 (NCoR1) is one of the most important proteins involved in myogenesis and metabolism. The results indicated that BZ significantly downregulated NCoR 1 expression, and further induced muscle differentiation and metabolism by regulating NCoR1‑associated gene expression in vivo and in vitro. In summary, the present study indicated that may be effective in combating weightlessness‑induced muscle atrophy. Combined with bioinformatics, the underlying mechanism for this decoction was investigated, which provided an improved understanding of this decoction.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu M, Liu Z, Gao M, Zhang Y, Li Y, Ling S, Zhang P, Zhao C, Jiang L, Liu Y, Liu Y, et al: The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms. Mol Med Rep 16: 5165-5174, 2017
APA
Zhu, M., Liu, Z., Gao, M., Zhang, Y., Li, Y., Ling, S. ... Li, Y. (2017). The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms. Molecular Medicine Reports, 16, 5165-5174. https://doi.org/10.3892/mmr.2017.7287
MLA
Zhu, M., Liu, Z., Gao, M., Zhang, Y., Li, Y., Ling, S., Zhang, P., Zhao, C., Jiang, L., Liu, Y., Li, Q., Li, D., Hu, S., Li, Y."The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms". Molecular Medicine Reports 16.4 (2017): 5165-5174.
Chicago
Zhu, M., Liu, Z., Gao, M., Zhang, Y., Li, Y., Ling, S., Zhang, P., Zhao, C., Jiang, L., Liu, Y., Li, Q., Li, D., Hu, S., Li, Y."The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms". Molecular Medicine Reports 16, no. 4 (2017): 5165-5174. https://doi.org/10.3892/mmr.2017.7287