Open Access

Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review)

  • Authors:
    • Shiqi She
    • Qucheng Wei
    • Bo Kang
    • Ying‑Jie Wang
  • View Affiliations

  • Published online on: September 13, 2017     https://doi.org/10.3892/mmr.2017.7489
  • Pages: 6459-6466
  • Copyright: © She et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Embryonic stem cells (ESCs) have unlimited expansion potential and the ability to differentiate into all somatic cell types for regenerative medicine and disease model studies. Octamer‑binding transcription factor 4 (OCT4), encoded by the POU domain, class 5, transcription factor 1 gene, is a transcription factor vital for maintaining ESC pluripotency and somatic reprogramming. Many studies have established that the cell cycle of ESCs is featured with an abbreviated G1 phase and a prolonged S phase. Changes in cell cycle dynamics are intimately associated with the state of ESC pluripotency, and manipulating cell‑cycle regulators could enable a controlled differentiation of ESCs. The present review focused primarily on the emerging roles of OCT4 in coordinating the cell cycle progression, the maintenance of pluripotency and the glycolytic metabolism in ESCs.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
She S, Wei Q, Kang B and Wang YJ: Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review). Mol Med Rep 16: 6459-6466, 2017
APA
She, S., Wei, Q., Kang, B., & Wang, Y. (2017). Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review). Molecular Medicine Reports, 16, 6459-6466. https://doi.org/10.3892/mmr.2017.7489
MLA
She, S., Wei, Q., Kang, B., Wang, Y."Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review)". Molecular Medicine Reports 16.5 (2017): 6459-6466.
Chicago
She, S., Wei, Q., Kang, B., Wang, Y."Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review)". Molecular Medicine Reports 16, no. 5 (2017): 6459-6466. https://doi.org/10.3892/mmr.2017.7489