Open Access

Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway

  • Authors:
    • Rui Jiang
    • Yiwei Shi
    • Chao Zeng
    • Wenyan Yu
    • Aizhen Zhang
    • Yongcheng Du
  • View Affiliations

  • Published online on: September 12, 2017     https://doi.org/10.3892/mmr.2017.7478
  • Pages: 6814-6820
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypoxic pulmonary hypertension (HPH) may contribute to vascular remodeling, and pulmonary artery smooth muscle cell (PASMC) proliferation has an important role in this process. However, no relevant information concerning the role and mechanism of protein kinase C (PKC)α in hypoxia‑induced rat PASMC proliferation has been elucidated. The present study aimed to further investigate this by comparison of rat PASMC proliferation among normoxia for 72 h (21% O2), hypoxia for 72 h (3% O2), hypoxia + promoter 12‑myristate 13‑acetate control, hypoxia + safingol control, hypoxia + PD98059 control and hypoxia + U0126 control groups. The present study demonstrated that protein expression levels of PKCα in rat PASMCs were elevated. In conclusion, through activating the extracellular signal‑regulated 1/2 signaling pathway, PKCα is involved in and initiates PASMC proliferation, thus bringing about pulmonary artery hypertension. These results add to the understanding of the mechanism PKCα in PH formation and lays a theoretical basis for prevention as well as treatment of HPH.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang R, Shi Y, Zeng C, Yu W, Zhang A and Du Y: Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway. Mol Med Rep 16: 6814-6820, 2017
APA
Jiang, R., Shi, Y., Zeng, C., Yu, W., Zhang, A., & Du, Y. (2017). Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway. Molecular Medicine Reports, 16, 6814-6820. https://doi.org/10.3892/mmr.2017.7478
MLA
Jiang, R., Shi, Y., Zeng, C., Yu, W., Zhang, A., Du, Y."Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway". Molecular Medicine Reports 16.5 (2017): 6814-6820.
Chicago
Jiang, R., Shi, Y., Zeng, C., Yu, W., Zhang, A., Du, Y."Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway". Molecular Medicine Reports 16, no. 5 (2017): 6814-6820. https://doi.org/10.3892/mmr.2017.7478