Open Access

Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses

  • Authors:
    • Hui Shi
    • Meiling Liang
    • Weiyan Chen
    • Xiuting Sun
    • Xiang Wang
    • Chenghsun Li
    • Yiying Yang
    • Zhisheng Yang
    • Wutao Zeng
  • View Affiliations

  • Published online on: November 15, 2017     https://doi.org/10.3892/mmr.2017.8075
  • Pages: 1461-1468
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The transplantation of mesenchymal stem cells (MSCs) has been a reported method for alleviating atherosclerosis (AS). Because the availability of bone marrow‑derived MSCs (BM‑MSCs) is limited, the authors used this study to explore the use of a new type of MSC, human induced pluripotent stem cell‑derived MSCs (iPSC‑MSCs), to evaluate whether these cells could alleviate AS. iPSC‑MSCs were intravenously administered to ApoE knock out mice fed on a high‑fat diet (HFD) for 12 weeks. It was reported that systematically administering iPSC‑MSCs clearly reduced the size of plaques. In addition, the numbers of macrophages and lipids in plaques were lower in the HFD + iPSC‑MSCs group than in the HFD group. Furthermore, iPSC‑MSCs attenuated AS‑associated inflammation by decreasing the levels of inflammatory cytokines, such as tumor necrosis factor‑α and interleukin‑6, in serum. In addition, the expression of Notch1 was higher in the HFD group, and injecting iPSC‑MSCs reversed this effect. In conclusion, the current study provides the first evidence indicating that iPSC‑MSCs may be a new optional MSC‑based strategy for treating AS.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shi H, Liang M, Chen W, Sun X, Wang X, Li C, Yang Y, Yang Z and Zeng W: Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses. Mol Med Rep 17: 1461-1468, 2018
APA
Shi, H., Liang, M., Chen, W., Sun, X., Wang, X., Li, C. ... Zeng, W. (2018). Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses. Molecular Medicine Reports, 17, 1461-1468. https://doi.org/10.3892/mmr.2017.8075
MLA
Shi, H., Liang, M., Chen, W., Sun, X., Wang, X., Li, C., Yang, Y., Yang, Z., Zeng, W."Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses". Molecular Medicine Reports 17.1 (2018): 1461-1468.
Chicago
Shi, H., Liang, M., Chen, W., Sun, X., Wang, X., Li, C., Yang, Y., Yang, Z., Zeng, W."Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses". Molecular Medicine Reports 17, no. 1 (2018): 1461-1468. https://doi.org/10.3892/mmr.2017.8075