Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats

  • Authors:
    • Xuyong Zhao
    • Yijia Xiang
    • Changhong Cai
    • Aiming Zhou
    • Ning Zhu
    • Chunlai Zeng
  • View Affiliations

  • Published online on: October 27, 2017     https://doi.org/10.3892/mmr.2017.7926
  • Pages: 556-561
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Abstract

The natural medicinal monomer, schisandrin B (Sch B), has been shown to exert cardioprotective effects; however, the underlying mechanisms of these effects remain to be fully elucidated. Therefore, the aim of the present study was to investigate whether Sch B attenuated myocardial ischemia/reperfusion (I/R) injury via the phosphoinositide 3‑kinases (PI3K)/Akt signaling pathway. To confirm this, I/R models were established in rats by ligation of the left anterior descending coronary artery. A group of animals were administered with Sch B (60 mg/kg, lavage) and/or the PI3K inhibitor, LY294002 (0.3 mg/kg, intraperitoneal). Myocardial infarct size, myocardial infarct serum markers, myocardial apoptotic index and the expression of Akt were measured in each group. The results demonstrated that the administration of Sch B reduced the size of the myocardial infarct, and this effect was eliminated following LY294002 treatment. In addition, the administration of Sch B decreased the apoptotic index and the serum markers of myocardial infarction. Sch B administration also increased the expression of phosphorylated Akt, and Sch B treatment decreased the B‑cell lymphoma 2 (Bcl‑2)‑like protein 4/Bcl‑2 ratio and the expression of cleaved caspase‑3. Therefore, Sch B may protect myocardial tissue from I/R injury via the PI3K/Akt signaling pathway in rats.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhao X, Xiang Y, Cai C, Zhou A, Zhu N and Zeng C: Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats. Mol Med Rep 17: 556-561, 2018
APA
Zhao, X., Xiang, Y., Cai, C., Zhou, A., Zhu, N., & Zeng, C. (2018). Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats. Molecular Medicine Reports, 17, 556-561. https://doi.org/10.3892/mmr.2017.7926
MLA
Zhao, X., Xiang, Y., Cai, C., Zhou, A., Zhu, N., Zeng, C."Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats". Molecular Medicine Reports 17.1 (2018): 556-561.
Chicago
Zhao, X., Xiang, Y., Cai, C., Zhou, A., Zhu, N., Zeng, C."Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats". Molecular Medicine Reports 17, no. 1 (2018): 556-561. https://doi.org/10.3892/mmr.2017.7926