Open Access

KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease

  • Authors:
    • Sen Wang
    • Yong Hou
    • Weiping Chen
    • Jianmin Wang
    • Weihua Xie
    • Xiaoping Zhang
    • Li Zeng
  • View Affiliations

  • Published online on: November 20, 2017     https://doi.org/10.3892/mmr.2017.8118
  • Pages: 2195-2202
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) are a novel group of non‑coding RNAs that are associated with inflammation and tumorigenesis. At present, the diagnostic efficacy of lncRNAs in inflammatory bowel disease (IBD) is unclear. The present study aimed to identify lncRNAs that may be used as potential biomarkers for IBD. The mRNA expression levels of various lncRNAs (KIF9‑AS1, LINC01272 and DIO3OS) were detected in tissue and plasma samples from patients with IBD by reverse transcription‑quantitative polymerase chain reaction. The results indicated that the mRNA expression levels of KIF9‑AS1 and LINC01272 were significantly upregulated in tissue and plasma samples from patients with IBD compared with in the healthy controls; conversely, the mRNA expression levels of DIO3OS were significantly downregulated in tissue and plasma samples from patients with IBD compared with in the healthy controls. Subsequently, the specificity and sensitivity of KIF9‑AS1, LINC01272 and DIO3OS were determined using a receiver operating characteristic (ROC) curve analysis. The results indicated that KIF9‑AS1, LINC01272 and DIO3OS had potential diagnostic value for the detection of IBD. Furthermore, there were significantly positive correlations in KIF9‑AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9‑AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang S, Hou Y, Chen W, Wang J, Xie W, Zhang X and Zeng L: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Mol Med Rep 17: 2195-2202, 2018
APA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., & Zeng, L. (2018). KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Molecular Medicine Reports, 17, 2195-2202. https://doi.org/10.3892/mmr.2017.8118
MLA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17.2 (2018): 2195-2202.
Chicago
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17, no. 2 (2018): 2195-2202. https://doi.org/10.3892/mmr.2017.8118