Open Access

UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer

  • Authors:
    • Xiang‑Rong Liu
    • Li‑Hua Zhou
    • Jian‑Xin Hu
    • Li‑Min Liu
    • Hui‑Ping Wan
    • Xi‑Quan Zhang
  • View Affiliations

  • Published online on: November 29, 2017     https://doi.org/10.3892/mmr.2017.8190
  • Pages: 2239-2244
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Triple-negative breast cancer (TNBC) is associated with an aggressive clinical history, high risk of recurrence and metastasis, and shorter patient survival due to lack of targeted therapy. In the present study, UNC0638, a chemical G9a inhibitor, was identified to suppress TNBC cell invasion and migration in vitro at a non‑cytotoxic concentration. In addition, UNC0638 reduced the size and number of the tumorsphere and decreased anchor‑independent colony formation in the two TNBC cell lines. Evaluation of the underlying mechanism revealed that the suppressive effect of UNC0638 is associated with modulation of epithelial‑mesenchymal transition through enhancing E‑cadherin promoter activities and restoring its expression. Thus, the current data indicates that UNC0638 may be developed as a chemotherapeutic agent to effectively treat metastatic cancers, including TNBC.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liu XR, Zhou LH, Hu JX, Liu LM, Wan HP and Zhang XQ: UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer. Mol Med Rep 17: 2239-2244, 2018
APA
Liu, X., Zhou, L., Hu, J., Liu, L., Wan, H., & Zhang, X. (2018). UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer. Molecular Medicine Reports, 17, 2239-2244. https://doi.org/10.3892/mmr.2017.8190
MLA
Liu, X., Zhou, L., Hu, J., Liu, L., Wan, H., Zhang, X."UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer". Molecular Medicine Reports 17.2 (2018): 2239-2244.
Chicago
Liu, X., Zhou, L., Hu, J., Liu, L., Wan, H., Zhang, X."UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer". Molecular Medicine Reports 17, no. 2 (2018): 2239-2244. https://doi.org/10.3892/mmr.2017.8190