Open Access

Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro

  • Authors:
    • Xiao‑Bo He
    • Tao Ma
    • Wei Zheng
    • Qing‑He Geng
    • Kai‑Jin Guo
  • View Affiliations

  • Published online on: November 20, 2017     https://doi.org/10.3892/mmr.2017.8105
  • Pages: 2271-2276
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aseptic loosening of artificial joints is the leading cause of failure for patients who receive total joint arthroplasty. Prior reports indicate that bone marrow mesenchymal stem cells (BSMC) are critical in the stabilization of implanted artificial joints, and that deregulated interaction between BMSCs and artificial joint derived particles is a risk factor for aseptic loosening with an unknown mechanism. In the present study, the pathomechanisms whereby titanium and its alloy derived particles facilitate aseptic loosing were investigated in vitro. It was demonstrated that nano‑sized titanium alloy particles significantly inhibited the proliferation of BMSCs in a time and concentration dependent manner. Furthermore, it was demonstrated that the particles promoted the apoptosis of BMSCs in the same manner. Bax and Caspase‑3 expression of BMSCs were elevated when cultured with the particles. As BMSCs exhibit a critical role in the stabilization of artificial joints, the results of the present study may provide a novel direction for the management of aseptic loosening in clinics.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
He XB, Ma T, Zheng W, Geng QH and Guo KJ: Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro. Mol Med Rep 17: 2271-2276, 2018
APA
He, X., Ma, T., Zheng, W., Geng, Q., & Guo, K. (2018). Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro. Molecular Medicine Reports, 17, 2271-2276. https://doi.org/10.3892/mmr.2017.8105
MLA
He, X., Ma, T., Zheng, W., Geng, Q., Guo, K."Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro". Molecular Medicine Reports 17.2 (2018): 2271-2276.
Chicago
He, X., Ma, T., Zheng, W., Geng, Q., Guo, K."Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro". Molecular Medicine Reports 17, no. 2 (2018): 2271-2276. https://doi.org/10.3892/mmr.2017.8105