Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia

  • Authors:
    • Sang‑Mi Woo
    • Kang Min Lee
    • Gyu Ri Lee
    • Ji Youn Park
    • Hee Jae Lee
    • Hyo‑Jung Bahn
    • Hyun Seok Yoon
    • Jem Yung Kim
    • Young Cheol Shin
    • Sung‑Gook Cho
    • Seong‑Gyu Ko
  • View Affiliations

  • Published online on: November 28, 2017     https://doi.org/10.3892/mmr.2017.8176
  • Pages: 2665-2672
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Abstract

Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. Several therapeutic strategies for the treatment of chemotherapy‑induced anorexia are available; however, their adverse effects limit their clinical use. Herbal medicines have a long history of use for the treatment of various diseases, including cancer, and recent research has demonstrated their safety and efficacy. In the present study, combinations of herbal medicines were designed based on traditional Korean medicine, and their effects were investigated on chemotherapy‑induced anorexia. Herbal mixtures were extracted, composed of Atractylodes japonica, Angelica gigas, Astragalus membranaceus, Lonicera japonica Thunb., Taraxacum platycarpum H. Dahlstedt and Prunella vulgaris var. asiatica (Nakai) Hara. The mixtures were termed LCBP‑Anocure‑16001‑3 (LA16001, LA16002, LA16003). A cisplatin‑induced anorexic mouse model was used to evaluate the putative effects of the extracts on chemotherapy‑induced anorexia. Treatment with LA16001 was revealed to prevent body weight loss, and all three extracts were demonstrated to improve food intake. When the molecular mechanisms underlying the orexigenic effects of LA16001 were investigated, altered expression levels of ghrelin, leptin and interleukin‑6 were revealed. Furthermore, LA16001 was reported to induce phosphorylation of Janus kinase 1 and signal transducer and activator of transcription 3. In addition, LA16001 administration increased the number of white blood cells and neutrophils. These results suggested that the herbal formula LA16001 may be able to prevent chemotherapy‑induced anorexia and may have potential as a novel therapeutic strategy for the adjuvant treatment of patients with cancer.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Woo SM, Lee KM, Lee GR, Park JY, Lee HJ, Bahn HJ, Yoon HS, Kim JY, Shin YC, Cho SG, Cho SG, et al: Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia. Mol Med Rep 17: 2665-2672, 2018
APA
Woo, S., Lee, K.M., Lee, G.R., Park, J.Y., Lee, H.J., Bahn, H. ... Ko, S. (2018). Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia. Molecular Medicine Reports, 17, 2665-2672. https://doi.org/10.3892/mmr.2017.8176
MLA
Woo, S., Lee, K. M., Lee, G. R., Park, J. Y., Lee, H. J., Bahn, H., Yoon, H. S., Kim, J. Y., Shin, Y. C., Cho, S., Ko, S."Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia". Molecular Medicine Reports 17.2 (2018): 2665-2672.
Chicago
Woo, S., Lee, K. M., Lee, G. R., Park, J. Y., Lee, H. J., Bahn, H., Yoon, H. S., Kim, J. Y., Shin, Y. C., Cho, S., Ko, S."Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia". Molecular Medicine Reports 17, no. 2 (2018): 2665-2672. https://doi.org/10.3892/mmr.2017.8176