Regulation of steroid hormones in the placenta and serum of women with preeclampsia

  • Authors:
    • Ye Young Shin
    • Jea Sic Jeong
    • Mee‑Na Park
    • Jae‑Eon Lee
    • Sung‑Min An
    • Wan‑Seob Cho
    • Seung Chul Kim
    • Beum‑Soo An
    • Kyu‑Sup Lee
  • View Affiliations

  • Published online on: November 27, 2017     https://doi.org/10.3892/mmr.2017.8165
  • Pages: 2681-2688
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Abstract

Preeclampsia (PE) is a pregnancy‑specific hypertensive syndrome that results in substantial maternal and fetal morbidity and mortality. The exact cause of PE has not been completely elucidate, although abnormal formation of the placenta has been considered. The placenta connects the developing fetus to the uterine wall, producing a large quantity of steroid hormones to maintain pregnancy. Although steroid hormones, particularly progesterone (P4) and estrogen (E2), in the serum of women with PE have been studied, steroidogenesis in the placenta has not well been established. The present study compared the concentrations of steroid hormones, including pregnenolone (PG), P4, dehydroepiandrosterone (DHEA), testosterone (T) and E2, in the serum and placenta of women with PE. PG, P4, DHEA and E2 concentrations tended to be decreased in PE serum and placentas, and the results were statistically significant for P4 and E2 in the serum. Quantification of genes associated with steroidogenesis in the placenta was performed, and the expression of the P4‑ and E2‑synthesizing enzymes testosterone 17‑β‑dehydrogenase 3 and 3 β‑hydroxysteroid dehydrogenase/δ5 4‑isomerase type 1 was reduced. Notably, aromatase, an enzyme required for the production of E2, was upregulated in the PE placenta, suggesting that steroidogenic enzymes may be dynamically regulated and may affect the symptoms of PE. In conclusion, the results of the present study suggested that the levels of steroid hormones, including P4 and E2, in the serum and placenta of women with PE are downregulated, which may be mediated by the regulation of steroidogenic enzyme expression in the PE placenta.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shin YY, Jeong JS, Park MN, Lee JE, An SM, Cho WS, Kim SC, An BS and Lee KS: Regulation of steroid hormones in the placenta and serum of women with preeclampsia. Mol Med Rep 17: 2681-2688, 2018
APA
Shin, Y.Y., Jeong, J.S., Park, M., Lee, J., An, S., Cho, W. ... Lee, K. (2018). Regulation of steroid hormones in the placenta and serum of women with preeclampsia. Molecular Medicine Reports, 17, 2681-2688. https://doi.org/10.3892/mmr.2017.8165
MLA
Shin, Y. Y., Jeong, J. S., Park, M., Lee, J., An, S., Cho, W., Kim, S. C., An, B., Lee, K."Regulation of steroid hormones in the placenta and serum of women with preeclampsia". Molecular Medicine Reports 17.2 (2018): 2681-2688.
Chicago
Shin, Y. Y., Jeong, J. S., Park, M., Lee, J., An, S., Cho, W., Kim, S. C., An, B., Lee, K."Regulation of steroid hormones in the placenta and serum of women with preeclampsia". Molecular Medicine Reports 17, no. 2 (2018): 2681-2688. https://doi.org/10.3892/mmr.2017.8165