Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice

  • Authors:
    • Xiaoxiao Zhao
    • Tingtao Chen
    • Fanjing Meng
    • Huan Wang
    • Puyuan Tian
    • Xianyao Tang
    • Xin Wang
    • Xiaolei Wang
    • Hongbo Xin
    • Hua Wei
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/mmr.2017.8150
  • Pages: 2764-2770
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Abstract

To minimize the waste of active ingredients present in herb residues, in the present study, probiotics of Bacillus subtilis, Aspergillus oryzae and Lactobacillus plantarum M3 were selected to reuse herb residues from Jianweixiaoshi tablets, and the therapeutic effects of the herb residue fermentation supernatant were evaluated using a spleen‑deficient mouse model. The results of the present study indicated that the fermentation supernatant may effectively improve the immunity of mice, as measured by body weight, spleen and thymus index, and inflammatory cytokines, including interleukin (IL)‑2, IL‑4 and interferon‑γ. The viable cell count and denaturing gradient gel electrophoresis results indicated that the fermentation supernatant markedly enhanced bacterial diversity and the number of lactobacilli in mouse intestines. Therefore, the combination of the Jianweixiaoshi herb residue and probiotics provided a novel method to reuse herb residues and may in the future contribute to the treatment of spleen deficiency.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhao X, Chen T, Meng F, Wang H, Tian P, Tang X, Wang X, Wang X, Xin H, Wei H, Wei H, et al: Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice. Mol Med Rep 17: 2764-2770, 2018
APA
Zhao, X., Chen, T., Meng, F., Wang, H., Tian, P., Tang, X. ... Wei, H. (2018). Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice. Molecular Medicine Reports, 17, 2764-2770. https://doi.org/10.3892/mmr.2017.8150
MLA
Zhao, X., Chen, T., Meng, F., Wang, H., Tian, P., Tang, X., Wang, X., Wang, X., Xin, H., Wei, H."Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice". Molecular Medicine Reports 17.2 (2018): 2764-2770.
Chicago
Zhao, X., Chen, T., Meng, F., Wang, H., Tian, P., Tang, X., Wang, X., Wang, X., Xin, H., Wei, H."Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice". Molecular Medicine Reports 17, no. 2 (2018): 2764-2770. https://doi.org/10.3892/mmr.2017.8150