Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice

  • Authors:
    • Yu Zhu
    • Jian Shen
    • Tianfu Sun
    • Hao Jiang
    • Kangli Xu
    • Thiti Samuthrat
    • Yicheng Xie
    • Yuxiang Weng
    • Yongda Li
    • Qiangmin Xie
    • Renya Zhan
  • View Affiliations

  • Published online on: December 11, 2017     https://doi.org/10.3892/mmr.2017.8236
  • Pages: 3170-3177
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Abstract

Radial glia are key neural progenitors involved in the development of the central nervous system. Tyrosine-protein phosphatase non‑receptor type 11 (Shp2) is a widely expressed intracellular enzyme with multiple cellular functions. Previous studies have revealed the critical role of Shp2 in a variety of neural cell types; however, further investigation into the function of Shp2 within radial glia is required. In the present study, a conditional knockout mouse was generated using a human glial fibrillary acidic protein (hGFAP)‑Cre driver, in which the Shp2 genes were deleted within radial glia. Loss of Shp2 within radial glia was associated with developmental retardation, postnatal lethality, reduced brain size and thinner cerebral cortices in newborn mice. Deletion of Shp2 also led to an increase in gliogenesis, a reduction in neural genesis and extracellular signal‑regulated kinase signaling within the cerebral cortex. Furthermore, glial cell defects within the cerebellum of Shp2 mutants were observed, with abnormal granular cell retention and glial cell alignment in the external granular layer. In addition, Shp2 mutants exhibited impaired sensory‑motor development. The results of the present study suggested that Shp2 may have an important role within radial glia, and regulate cerebral cortical and cerebellar development in newborn mice.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu Y, Shen J, Sun T, Jiang H, Xu K, Samuthrat T, Xie Y, Weng Y, Li Y, Xie Q, Xie Q, et al: Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice. Mol Med Rep 17: 3170-3177, 2018
APA
Zhu, Y., Shen, J., Sun, T., Jiang, H., Xu, K., Samuthrat, T. ... Zhan, R. (2018). Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice. Molecular Medicine Reports, 17, 3170-3177. https://doi.org/10.3892/mmr.2017.8236
MLA
Zhu, Y., Shen, J., Sun, T., Jiang, H., Xu, K., Samuthrat, T., Xie, Y., Weng, Y., Li, Y., Xie, Q., Zhan, R."Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice". Molecular Medicine Reports 17.2 (2018): 3170-3177.
Chicago
Zhu, Y., Shen, J., Sun, T., Jiang, H., Xu, K., Samuthrat, T., Xie, Y., Weng, Y., Li, Y., Xie, Q., Zhan, R."Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice". Molecular Medicine Reports 17, no. 2 (2018): 3170-3177. https://doi.org/10.3892/mmr.2017.8236