Open Access

Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury

  • Authors:
    • Shuai Jiang
    • Xing‑Cheng Zhao
    • Bo Jiao
    • Zhi‑Jie Yue
    • Zhi‑Bin Yu
  • View Affiliations

  • Published online on: January 25, 2018     https://doi.org/10.3892/mmr.2018.8489
  • Pages: 5150-5158
  • Copyright : © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The gravitational field is an important determinant of cardiovascular function. Exposure to microgravity during spaceflight may lead to a series of maladaptive alterations in the cardiovascular system. The authors have previously demonstrated that microgravity can increase the susceptibility to myocardial ischemia‑reperfusion (IR) injury under simulated microgravity. Although Notch1 signaling protects against myocardial IR injury, whether Notch1 protects against myocardial IR injury under simulated weightlessness remains unknown. The present study is designed to investigate the role of the Notch1 receptor in myocardial IR injury under simulated weightlessness. The differences in Notch signaling expression and myocardial infarct size following myocardial IR were compared between normal rats and tail‑suspended rats that were kept in 30˚ head‑down tilt and hindlimb unloading position. The data revealed low expression levels of Notch1 receptor and its endogenous ligand Jagged1 in normal adult rat hearts. However, significantly higher expression of Notch1 was observed in the border zone compared with the infarcted area and the remote zone following myocardial IR. Notch1 expression was notably reduced in the infarcted hearts of tail‑suspended rats compared with the control group. Conversely, the myocardial infarct size was significantly increased in tail‑suspended rats compared with the control rats. In conclusion, these data suggested that the proper function of Notch signaling may be hampered under simulated microgravity.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang S, Zhao XC, Jiao B, Yue ZJ and Yu ZB: Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury. Mol Med Rep 17: 5150-5158, 2018
APA
Jiang, S., Zhao, X., Jiao, B., Yue, Z., & Yu, Z. (2018). Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury. Molecular Medicine Reports, 17, 5150-5158. https://doi.org/10.3892/mmr.2018.8489
MLA
Jiang, S., Zhao, X., Jiao, B., Yue, Z., Yu, Z."Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury". Molecular Medicine Reports 17.4 (2018): 5150-5158.
Chicago
Jiang, S., Zhao, X., Jiao, B., Yue, Z., Yu, Z."Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia‑reperfusion injury". Molecular Medicine Reports 17, no. 4 (2018): 5150-5158. https://doi.org/10.3892/mmr.2018.8489