Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases

  • Authors:
    • Xiaomeng Li
    • Gene Moon
    • Sook Shin
    • Bin Zhang
    • Ralf Janknecht
  • View Affiliations

  • Published online on: January 26, 2018     https://doi.org/10.3892/mmr.2018.8507
  • Pages: 5518-5527
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Abstract

The E26 transformation-specific (ETS) variant 2 (ETV2) protein, also designated as ETS-related 71, is a member of the ETS transcription factor family and is essential for blood and vascular development in the embryo. The role of ETV2 in cancer has not yet been investigated. In the present study, the expression of ETV2 mRNA was identified in a variety of tumor types, including prostate carcinoma. In addition, ETV2 gene amplification was identified in several types of cancer, suggesting that ETV2 plays an oncogenic role in tumorigenesis. It was demonstrated that ETV2 forms complexes with two histone demethylases: Jumonji domain‑containing (JMJD)2A and JMJD2D; JMJD2A has been previously reported as a driver of prostate cancer development. In the present study, it was reported that ETV2 exhibited the potential to stimulate the promoters of matrix metalloproteinases (MMPs), including MMP1 and MMP7, within LNCaP prostate cancer cells. JMJD2A and JMJD2D could synergize with ETV2 to activate the MMP1 promoter, whereas only JMJD2A stimulated the MMP7 promoter in cooperation with ETV2. Furthermore, ETV2 expression was positively associated with JMJD2A and JMJD2D mRNA levels in neuroendocrine prostate tumors, in which an ETV2 gene amplification rate of 17.8% was identified. Collectively, the results of the present study indicated that ETV2, JMJD2A and JMJD2D may jointly promote tumorigenesis, particularly neuroendocrine prostate tumors. In addition, the interaction with the JMJD2A and JMJD2D epigenetic regulators may be important in the ability of ETV2 to reprogram cells, modulate normal and cancer stem cells, and affect spermatogenesis.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li X, Moon G, Shin S, Zhang B and Janknecht R: Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. Mol Med Rep 17: 5518-5527, 2018
APA
Li, X., Moon, G., Shin, S., Zhang, B., & Janknecht, R. (2018). Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. Molecular Medicine Reports, 17, 5518-5527. https://doi.org/10.3892/mmr.2018.8507
MLA
Li, X., Moon, G., Shin, S., Zhang, B., Janknecht, R."Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases". Molecular Medicine Reports 17.4 (2018): 5518-5527.
Chicago
Li, X., Moon, G., Shin, S., Zhang, B., Janknecht, R."Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases". Molecular Medicine Reports 17, no. 4 (2018): 5518-5527. https://doi.org/10.3892/mmr.2018.8507