Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression

  • Authors:
    • Xinli Mao
    • Hongyuan Zhu
    • Dinghai Luo
    • Liping Ye
    • Huifei Yin
    • Jinshun Zhang
    • Yan Zhang
    • Yu Zhang
  • View Affiliations

  • Published online on: February 8, 2018     https://doi.org/10.3892/mmr.2018.8574
  • Pages: 6116-6121
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Abstract

Capsaicin is a principal component of hot red peppers and chili peppers. Previous studies have reported that capsaicin exhibits antitumor functions in a variety of tumor models. Although various mechanisms underlying the capsaicin‑mediated inhibition of tumor growth have been demonstrated, the impact of capsaicin on tumor metabolism has rarely been reported. The present study demonstrated that capsaicin exhibited an inhibitory effect on tumor glycolysis in esophageal squamous cell carcinoma (ESCC) cells. Following treatment with capsaicin, glucose consumption and lactate production in ESCC cells was decreased. Capsaicin resulted in a decrease of hexokinase‑2 (HK‑2) expression, which is known for its important role in tumor glycolysis. Further investigations demonstrated that phosphatase and tensin homolog (PTEN) expression was increased in ESCC cells treated with capsaicin, and that the RAC‑α serine threonine‑protein kinase signaling pathway was downregulated. In PTEN‑knockdown KYSE150 cells, the decrease in HK‑2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Mao X, Zhu H, Luo D, Ye L, Yin H, Zhang J, Zhang Y and Zhang Y: Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression. Mol Med Rep 17: 6116-6121, 2018
APA
Mao, X., Zhu, H., Luo, D., Ye, L., Yin, H., Zhang, J. ... Zhang, Y. (2018). Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression. Molecular Medicine Reports, 17, 6116-6121. https://doi.org/10.3892/mmr.2018.8574
MLA
Mao, X., Zhu, H., Luo, D., Ye, L., Yin, H., Zhang, J., Zhang, Y., Zhang, Y."Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression". Molecular Medicine Reports 17.4 (2018): 6116-6121.
Chicago
Mao, X., Zhu, H., Luo, D., Ye, L., Yin, H., Zhang, J., Zhang, Y., Zhang, Y."Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression". Molecular Medicine Reports 17, no. 4 (2018): 6116-6121. https://doi.org/10.3892/mmr.2018.8574