Open Access

miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels

  • Authors:
    • Feihu Bai
    • Mengna Jiu
    • Yanjie You
    • Yaning Feng
    • Ruijuan Xin
    • Xiaogang Liu
    • Lirong Mo
    • Yongzhan Nie
  • View Affiliations

  • Published online on: April 19, 2018     https://doi.org/10.3892/mmr.2018.8896
  • Pages: 8145-8152
  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA‑29a (miR‑29a) has recently been in the spotlight as a tumor suppressor whose encoding gene is frequently suppressed in cancers. The aim of the present study was to investigate the biological functions and underlying molecular mechanism by which miR‑29a‑3p suppresses gastric cancer peritoneum metastasis. Cell proliferation, colony‑forming, wound healing and Transwell migration assays were performed in the present study. MiR‑29a‑3p expression was markedly decreased in gastric cancer cell lines with stronger metastatic potential. Silencing miR‑29a‑3p expression promoted gastric cancer cell proliferation, colony‑forming, migration and invasion. By contrast, overexpression of miR‑29a‑3p inhibited these biological phenotypes. In addition, it was revealed that miR‑29a‑3p functioned through downregulating hyaluronan synthase 3 expression. Collectively, dysregulated miR‑29a‑3p expression in gastric cancer cells was associated with malignant properties primarily relevant to migration and metastasis. The results suggest that miR‑29a‑3p may be a potential therapeutic target for gastric cancer.
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June-2018
Volume 17 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Bai F, Jiu M, You Y, Feng Y, Xin R, Liu X, Mo L and Nie Y: miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels. Mol Med Rep 17: 8145-8152, 2018
APA
Bai, F., Jiu, M., You, Y., Feng, Y., Xin, R., Liu, X. ... Nie, Y. (2018). miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels. Molecular Medicine Reports, 17, 8145-8152. https://doi.org/10.3892/mmr.2018.8896
MLA
Bai, F., Jiu, M., You, Y., Feng, Y., Xin, R., Liu, X., Mo, L., Nie, Y."miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels". Molecular Medicine Reports 17.6 (2018): 8145-8152.
Chicago
Bai, F., Jiu, M., You, Y., Feng, Y., Xin, R., Liu, X., Mo, L., Nie, Y."miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels". Molecular Medicine Reports 17, no. 6 (2018): 8145-8152. https://doi.org/10.3892/mmr.2018.8896