Open Access

Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis

  • Authors:
    • Zhe Wang
    • Yudi Han
    • Zhaoqing Zhang
    • Cunfeng Jia
    • Qiang Zhao
    • Wei Song
    • Tao Chen
    • Yifan Zhang
    • Xiuhui Wang
  • View Affiliations

  • Published online on: June 6, 2018     https://doi.org/10.3892/mmr.2018.9136
  • Pages: 1263-1270
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed to identify differentially expressed genes (DEGs) associated with disease characteristics. Additionally, Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the DEGs were performed. Protein‑protein, microRNA‑transcription factor and chemical‑gene interaction networks were constructed. A total of 326 DEGs, 196 upregulated and 130 downregulated, were identified. DEGs, including C‑X‑C motif chemokine ligand 5 (CXCL5), BCL2 interacting protein 3 like (BNIP3L), dual specificity phosphatase 5 (DUSP5) and tumor protein p53 (TP53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. KEGG pathway enrichment analysis revealed that pathways associated with inflammation and the mitogen‑activated protein kinase 1 (MAPK) signaling pathway were the most enriched by DEGs. The results of the present study indicated that the MAPK signaling pathway and four genes, including CXCL5, BNIP3L, DUSP5 and TP53, may be implicated in the pathogenesis of JSA.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Z, Han Y, Zhang Z, Jia C, Zhao Q, Song W, Chen T, Zhang Y and Wang X: Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis. Mol Med Rep 18: 1263-1270, 2018
APA
Wang, Z., Han, Y., Zhang, Z., Jia, C., Zhao, Q., Song, W. ... Wang, X. (2018). Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis. Molecular Medicine Reports, 18, 1263-1270. https://doi.org/10.3892/mmr.2018.9136
MLA
Wang, Z., Han, Y., Zhang, Z., Jia, C., Zhao, Q., Song, W., Chen, T., Zhang, Y., Wang, X."Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis". Molecular Medicine Reports 18.2 (2018): 1263-1270.
Chicago
Wang, Z., Han, Y., Zhang, Z., Jia, C., Zhao, Q., Song, W., Chen, T., Zhang, Y., Wang, X."Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis". Molecular Medicine Reports 18, no. 2 (2018): 1263-1270. https://doi.org/10.3892/mmr.2018.9136