Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion

  • Authors:
    • Xin Wang
    • Kui‑Di Liang
    • Jun‑Ai Zhang
    • Gan‑Bin Liu
    • Zhi Chen
    • Chen Chen
    • Ze‑Gang Zhuang
    • Yu‑Qing Liu
    • Hou‑Long Luo
    • Rui Xi Li
    • Bi‑Ying Zheng
    • Jun‑Fa Xu
  • View Affiliations

  • Published online on: May 25, 2018     https://doi.org/10.3892/mmr.2018.9073
  • Pages: 1704-1709
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Abstract

B cell activating factor (BAFF), a member of the tumor necrosis factor family, is a key cytokine for B cell survival, a function that is essential for B cell maturation and memory. The expression levels of BAFF and its potential contribution to B cell maturation remain elusive in patients with tuberculous pleural effusion (TPE). The present study enrolled 40 healthy controls (HC) and 45 TPE patients, and investigated the levels of BAFF in the plasma and pleural effusion. Concomitantly, B cell subsets including naïve B cell (CD19+IgD+CD27‑), unswitched B cell (CD19+IgD+CD27+), switched B cell (CD19+IgD‑CD27+), total memory B cell (CD19+CD27+), plasma B cell (CD19+IgD‑CD38+CD27+) and transitional B cell (CD19+IgDdim CD38+) in peripheral blood mononuclear cells (PBMCs) and pleural fluid mononuclear cells (PFMCs) were assessed using multicolor flow cytometry. Finally, the associations between BAFF and each sub‑group of B cells in TPE patients were analyzed. Compared with HC cases, an increased BAFF level and elevated frequency of switched B cell were observed in the blood and pleural effusion from patients with TPE. The proportions of naïve B cell, plasma B cell and transitional B cell were lower in the PFMCs of TPE patients. Furthermore, a significant correlation was observed between the level of BAFF, and the proportion of switched B cell in the peripheral blood and pleural effusion of TPE patients. These findings indicated that the B cell profile may be different in the pleural effusion, and BAFF may activate switched B cells to enhance the humoral immune responses in patients with TPE. Further studies are required to elucidate the underlying mechanisms and determine the potential immunotherapy of the BAFF‑switched B cell axis.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang X, Liang KD, Zhang JA, Liu GB, Chen Z, Chen C, Zhuang ZG, Liu YQ, Luo HL, Li RX, Li RX, et al: Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion. Mol Med Rep 18: 1704-1709, 2018
APA
Wang, X., Liang, K., Zhang, J., Liu, G., Chen, Z., Chen, C. ... Xu, J. (2018). Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion. Molecular Medicine Reports, 18, 1704-1709. https://doi.org/10.3892/mmr.2018.9073
MLA
Wang, X., Liang, K., Zhang, J., Liu, G., Chen, Z., Chen, C., Zhuang, Z., Liu, Y., Luo, H., Li, R. X., Zheng, B., Xu, J."Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion". Molecular Medicine Reports 18.2 (2018): 1704-1709.
Chicago
Wang, X., Liang, K., Zhang, J., Liu, G., Chen, Z., Chen, C., Zhuang, Z., Liu, Y., Luo, H., Li, R. X., Zheng, B., Xu, J."Increased B cell activating factor is associated with B cell class switching in patients with tuberculous pleural effusion". Molecular Medicine Reports 18, no. 2 (2018): 1704-1709. https://doi.org/10.3892/mmr.2018.9073