Open Access

Therapeutic effects of bee venom on experimental atopic dermatitis

  • Authors:
    • Hyemin Gu
    • Woon‑Hae Kim
    • Hyun‑Jin An
    • Jung‑Yeon Kim
    • Mi‑Gyeong Gwon
    • Sang Mi Han
    • Jaechan Leem
    • Kwan‑Kyu Park
  • View Affiliations

  • Published online on: August 17, 2018     https://doi.org/10.3892/mmr.2018.9398
  • Pages: 3711-3718
  • Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by recurrent eczema and itching. It is caused by a poorly controlled immune response and damage to the skin barrier. Purified bee venom (BV) is a natural toxin produced by honeybees (Apis mellifera L.), and is well known for its anti‑inflammatory, analgesic and anti‑cancer effects against various types of disease. However, treatment strategies based on anti‑inflammatory properties have not been adequately studied in AD. Thus, the present study examined the progression of AD‑like skin lesions induced by ovalbumin (OVA) and the mechanism of action of BV. BV, administered by intraperitoneal inoculation, was observed to reduce the symptoms of AD, in addition to the serum immunoglobulin E levels, according to dorsal skin thickness and histopathologic analysis. The treatment also inhibited the infiltration of eosinophils and mast cells. These results suggested that it is possible to develop novel AD alternative therapy using BV by effectively suppressing allergic skin inflammation in AD.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 18 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gu H, Kim WH, An HJ, Kim JY, Gwon MG, Han SM, Leem J and Park KK: Therapeutic effects of bee venom on experimental atopic dermatitis. Mol Med Rep 18: 3711-3718, 2018
APA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S.M. ... Park, K. (2018). Therapeutic effects of bee venom on experimental atopic dermatitis. Molecular Medicine Reports, 18, 3711-3718. https://doi.org/10.3892/mmr.2018.9398
MLA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18.4 (2018): 3711-3718.
Chicago
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18, no. 4 (2018): 3711-3718. https://doi.org/10.3892/mmr.2018.9398