Open Access

Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells

  • Authors:
    • Dong‑Li Hu
    • Guo Wang
    • Jing Yu
    • Li‑Hua Zhang
    • Yuan‑Fei Huang
    • Dan Wang
    • Hong‑Hao Zhou
  • View Affiliations

  • Published online on: January 3, 2019     https://doi.org/10.3892/mmr.2019.9816
  • Pages: 1509-1520
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

(‑)‑Epigallocatechin‑3‑gallate (EGCG), a major constituent of green tea, is a potential anticancer agent, but the molecular mechanisms of its effects are not well‑understood. The present study was conducted to examine the mechanism of EGCG in lung cancer cells. Alterations in long non‑coding RNAs (lncRNAs) and mRNAs were investigated in lung cancer cells treated with EGCG by lncRNA microarray analysis. Furthermore, the functions and signaling pathways regulated by EGCG were predicted by bioinformatics analysis. A total of 960 lncRNAs and 1,434 mRNAs were significantly altered following EGCG treatment. These lncRNAs were distributed across nearly all human chromosomes and the mRNAs were involved in the cell cycle and the mitotic cell cycle process. Through a combination of microarray and bioinformatics analysis, 20 mRNAs predicted to serve a key role in the EGCG regulation were identified, and certain regulatory networks involving EGCG‑regulated lncRNAs were predicted. In conclusion, EGCG affects the expression of various lncRNAs and mRNAs in the cells, therefore affecting cell functions. The results of the present study provide an insight into the mechanism of EGCG, which may be useful for therapeutic development.
View Figures
View References

Related Articles

Journal Cover

March-2019
Volume 19 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hu DL, Wang G, Yu J, Zhang LH, Huang YF, Wang D and Zhou HH: Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells. Mol Med Rep 19: 1509-1520, 2019
APA
Hu, D., Wang, G., Yu, J., Zhang, L., Huang, Y., Wang, D., & Zhou, H. (2019). Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells. Molecular Medicine Reports, 19, 1509-1520. https://doi.org/10.3892/mmr.2019.9816
MLA
Hu, D., Wang, G., Yu, J., Zhang, L., Huang, Y., Wang, D., Zhou, H."Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells". Molecular Medicine Reports 19.3 (2019): 1509-1520.
Chicago
Hu, D., Wang, G., Yu, J., Zhang, L., Huang, Y., Wang, D., Zhou, H."Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells". Molecular Medicine Reports 19, no. 3 (2019): 1509-1520. https://doi.org/10.3892/mmr.2019.9816