Open Access

The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection

  • Authors:
    • Dong Shao
    • Zhouquan Wu
    • Shuying Bai
    • Guowei Fu
    • Zhiqing Zou
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/mmr.2019.10056
  • Pages: 4001-4010
  • Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the function of micro (mi)RNA‑153 against isoflurane‑induced neurotoxicity and its mechanism. In isoflurane‑induced mice, miRNA‑153 expression was downregulated compared with in the control group. Downregulation of miRNA‑153 induced neurocyte apoptosis, reduced cell growth and promoted oxidative stress in an in vitro model. Overexpression of miRNA‑153 reduced oxidative stress, promoted cell growth and inhibited neurocyte apoptosis within an in vitro model. Downregulation of miRNA‑153 suppressed nuclear erythroid‑2 related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, which was induced via the overexpression of miRNA‑153 in vitro. The Nrf2 agonist, dimethyl fumarate (2.5 µM), induced the Nrf2/ARE signaling pathway and reduced oxidative stress to induce neurocyte apoptosis in vitro following treatment with anti‑miRNA‑153. The results of the present study suggested the function of miRNA‑153 against neurotoxicity via Nrf2/ARE‑mediated cytoprotection.
View Figures
View References

Related Articles

Journal Cover

May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shao D, Wu Z, Bai S, Fu G and Zou Z: The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection. Mol Med Rep 19: 4001-4010, 2019
APA
Shao, D., Wu, Z., Bai, S., Fu, G., & Zou, Z. (2019). The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection. Molecular Medicine Reports, 19, 4001-4010. https://doi.org/10.3892/mmr.2019.10056
MLA
Shao, D., Wu, Z., Bai, S., Fu, G., Zou, Z."The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection". Molecular Medicine Reports 19.5 (2019): 4001-4010.
Chicago
Shao, D., Wu, Z., Bai, S., Fu, G., Zou, Z."The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection". Molecular Medicine Reports 19, no. 5 (2019): 4001-4010. https://doi.org/10.3892/mmr.2019.10056