Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats

  • Authors:
    • Qing-Ling Zhong
    • Fan-Rong Liu
    • De-Wu Liu
    • Yan Peng
    • Xiang-Rong Zhang
  • View Affiliations

  • Published online on: January 25, 2011     https://doi.org/10.3892/mmr.2011.435
  • Pages: 377-381
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms invovled in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction of β-catenin and its downstream target in ESCs, cyclin D1, lead to poor wound healing in diabetes mellitus (DM). We found that, compared to the controls, the ESCs of diabetic rats were markedly reduced, the clone formation efficiency of the ESCs was markedly lower, and the mRNA and protein expression of β-catenin and cyclin D1 was significantly decreased. These findings suggest that the low expression of β-catenin and cyclin D1 may reduce the activity of ESCs from diabetic rats, which might be one of the important mechanisms of delayed wound healing in DM.

Related Articles

Journal Cover

March-April 2011
Volume 4 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhong Q, Liu F, Liu D, Peng Y and Zhang X: Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Mol Med Rep 4: 377-381, 2011
APA
Zhong, Q., Liu, F., Liu, D., Peng, Y., & Zhang, X. (2011). Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Molecular Medicine Reports, 4, 377-381. https://doi.org/10.3892/mmr.2011.435
MLA
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4.2 (2011): 377-381.
Chicago
Zhong, Q., Liu, F., Liu, D., Peng, Y., Zhang, X."Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats". Molecular Medicine Reports 4, no. 2 (2011): 377-381. https://doi.org/10.3892/mmr.2011.435