Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp

  • Authors:
    • Yan Li
    • Ke Tang
    • Haijing Zhang
    • Yi Zhang
    • Wanqi Zhou
    • Xiaoguang Chen
  • View Affiliations

  • Published online on: May 16, 2011     https://doi.org/10.3892/mmr.2011.494
  • Pages: 739-746
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Breast cancer is one of the most common malignant diseases among women. In early and metastatic breast cancer, Taxane (Taxol) is widely used as an adjuvant and neoadjuvant therapies. Although breast cancer is initially responsive to Taxol, inherent or developed resistance to Taxol often limits the efficacy of the drug. The oncogene Aurora kinase A is frequently up-regulated in human cancer, and is associated with sensitivity to chemotherapy in certain types of cancer. In the present study, we aimed to clarify the functional role of Aurora kinase A in breast cancer resistance to Taxol, and to determine the means to overcome this resistance. The correlation between the expression levels of Aurora kinase A and chemoresistance to Taxol in breast cancer cells, and resistance to Taxol in a xenograft model were demonstrated. MTT assay was performed to determine cell viability. Subsequently, the relationship of Aurora kinase A with the expression and functional role of P-gp was clarified, as well as its relationship with p-ERK2, which regulates the expression of P-gp. The expression of Aurora A was determined to be capable of enhancing the sensitivity of cells resistant to Taxol in vitro and in vivo using stable knockdown Aurora kinase A cells. We propose that this kinase may be used as a target for overcoming chemoresistance and enhancing the chemosensitivity of breast cancer to Taxol.

Related Articles

Journal Cover

July-August 2011
Volume 4 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Tang K, Zhang H, Zhang Y, Zhou W and Chen X: Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp. Mol Med Rep 4: 739-746, 2011
APA
Li, Y., Tang, K., Zhang, H., Zhang, Y., Zhou, W., & Chen, X. (2011). Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp. Molecular Medicine Reports, 4, 739-746. https://doi.org/10.3892/mmr.2011.494
MLA
Li, Y., Tang, K., Zhang, H., Zhang, Y., Zhou, W., Chen, X."Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp". Molecular Medicine Reports 4.4 (2011): 739-746.
Chicago
Li, Y., Tang, K., Zhang, H., Zhang, Y., Zhou, W., Chen, X."Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp". Molecular Medicine Reports 4, no. 4 (2011): 739-746. https://doi.org/10.3892/mmr.2011.494