Obtain osteoarthritis related molecular signature genes through regulation network

  • Authors:
    • Yawei Li
    • Bing Wang
    • Guohua Lv
    • Guangzhong Xiong
    • Wei Dong Liu
    • Lei Li
  • View Affiliations

  • Published online on: September 22, 2011     https://doi.org/10.3892/mmr.2011.595
  • Pages: 177-183
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Abstract

Osteoarthritis (OA), also known as degenerative joint disease or osteoarthrosis, is the most common form of arthritis. OA occurs when cartilage in the joints wears down over time. We used the GSE1919 series to identify potential genes that correlated to OA. The aim of our study was to obtain a molecular signature of OA through the regulation network based on differentially expressed genes. From the result of regulation network construction in OA, a number of transcription factors (TFs) and pathways closely related to OA were linked by our method. Peroxisome proliferator-activated receptor γ also arises as hub nodes in our transcriptome network and certain TFs containing CEBPD, EGR2 and ETS2 were shown to be related to OA by a previous study.

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January 2012
Volume 5 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li Y, Wang B, Lv G, Xiong G, Liu W and Li L: Obtain osteoarthritis related molecular signature genes through regulation network. Mol Med Rep 5: 177-183, 2012
APA
Li, Y., Wang, B., Lv, G., Xiong, G., Liu, W., & Li, L. (2012). Obtain osteoarthritis related molecular signature genes through regulation network. Molecular Medicine Reports, 5, 177-183. https://doi.org/10.3892/mmr.2011.595
MLA
Li, Y., Wang, B., Lv, G., Xiong, G., Liu, W., Li, L."Obtain osteoarthritis related molecular signature genes through regulation network". Molecular Medicine Reports 5.1 (2012): 177-183.
Chicago
Li, Y., Wang, B., Lv, G., Xiong, G., Liu, W., Li, L."Obtain osteoarthritis related molecular signature genes through regulation network". Molecular Medicine Reports 5, no. 1 (2012): 177-183. https://doi.org/10.3892/mmr.2011.595