Crosstalk between dopamine receptors and the Na+/K+‑ATPase (Review)

  • Authors:
    • Li‑Nan Zhang
    • Jun‑Xia Li
    • Liang Hao
    • Yong‑Jun Sun
    • Ying‑Hua Xie
    • Shao‑Mei Wu
    • Lei Liu
    • Xiao-Long Chen
    • Zi-Bin Gao
  • View Affiliations

  • Published online on: September 19, 2013     https://doi.org/10.3892/mmr.2013.1697
  • Pages: 1291-1299
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Abstract

Dopamine (DA) receptors, which belong to the G protein‑coupled receptor family, are the target of ~50% of all modern medicinal drugs and constitute a large and diverse class of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. Na+/K+‑ATPase (NKA) is ubiquitous and crucial for the maintenance of intracellular ion homeostasis and excitability. Furthermore, it plays a critical role in diverse effects, including clinical cardiotonic and cardioprotective effects, ischemic preconditioning in the brain, natriuresis, lung edema clearance and other processes. NKA regulation is of physiological and pharmacological importance and has species‑ and tissue‑specific variations. The activation of DA receptors regulates NKA expression/activity and trafficking in various tissues and cells, for example in the kidney, lung, intestine, brain, non‑pigmented ciliary epithelium and the vascular bed. DA receptor‑mediated regulation of NKA mediates a diverse range of cellular responses and includes endocytosis/exocytosis, phosphorylation/dephosphorylation of the α subunit of NKA and multiple signaling pathways, including phosphatidylinositol (PI)‑phospholipase C/protein kinase (PK) C, cAMP/PKA, PI3K, adaptor protein 2, tyrosine phosphatase and mitogen‑activated protein kinase/extracellular signal‑regulated protein kinase. Furthermore, in brain and HEK293T cells, D1 and D2 receptors exist in a complex with NKA. Among D1 and D2 receptors and NKA, regulations are reciprocal, which leads to crosstalk between DA receptors and NKA. In the present study, the current understanding of signaling mechanisms responsible for the crosstalk between DA receptors and NKA, as well as with specific consequent functions, is reviewed.
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November 2013
Volume 8 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang LN, Li JX, Hao L, Sun YJ, Xie YH, Wu SM, Liu L, Chen X and Gao Z: Crosstalk between dopamine receptors and the Na+/K+‑ATPase (Review). Mol Med Rep 8: 1291-1299, 2013
APA
Zhang, L., Li, J., Hao, L., Sun, Y., Xie, Y., Wu, S. ... Gao, Z. (2013). Crosstalk between dopamine receptors and the Na+/K+‑ATPase (Review). Molecular Medicine Reports, 8, 1291-1299. https://doi.org/10.3892/mmr.2013.1697
MLA
Zhang, L., Li, J., Hao, L., Sun, Y., Xie, Y., Wu, S., Liu, L., Chen, X., Gao, Z."Crosstalk between dopamine receptors and the Na+/K+‑ATPase (Review)". Molecular Medicine Reports 8.5 (2013): 1291-1299.
Chicago
Zhang, L., Li, J., Hao, L., Sun, Y., Xie, Y., Wu, S., Liu, L., Chen, X., Gao, Z."Crosstalk between dopamine receptors and the Na+/K+‑ATPase (Review)". Molecular Medicine Reports 8, no. 5 (2013): 1291-1299. https://doi.org/10.3892/mmr.2013.1697