Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer (Review)

  • Authors:
    • Dan Song
    • Hong Li
    • Haibo Li
    • Jianrong Dai
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  • Published online on: May 29, 2015     https://doi.org/10.3892/ol.2015.3295
  • Pages: 600-606
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Abstract

Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce immune evasion of the infected cells, which enable the virus to be undetectable for long periods of time. The induction of immunotolerance of the host's immune system by the persistent infection of HPV is one of the most important mechanisms for cervical lesions. The present review elaborates on the roles of several types of immune cells, such as macrophages and natural killer cells, which are classified as innate immune cells, and dendritic cells (DCs), cluster of differentiation (CD)4+/CD8+ T cells and regulatory T cells, which are classified as adaptive immune cells. HPV infection could effect the differentiation of these immune cells in a unique way, resulting in the host's immune tolerance to the infection. The immune system modifications induced by HPV infection include tumor‑associated macrophage differentiation, a compromised cellular immune response, an abnormal imbalance between type 1 T‑helper cells (Th1) and Th2 cells, regulatory T cell infiltration, and downregulated DC activation and maturation. To date, numerous types of preventative vaccines have been created to slow down carcinogenesis. Immune response activation‑based therapeutic vaccine is becoming more and more attractive for the treatment of HPV-associated diseases.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Song D, Li H, Li H and Dai J: Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer (Review). Oncol Lett 10: 600-606, 2015
APA
Song, D., Li, H., Li, H., & Dai, J. (2015). Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer (Review). Oncology Letters, 10, 600-606. https://doi.org/10.3892/ol.2015.3295
MLA
Song, D., Li, H., Li, H., Dai, J."Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer (Review)". Oncology Letters 10.2 (2015): 600-606.
Chicago
Song, D., Li, H., Li, H., Dai, J."Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer (Review)". Oncology Letters 10, no. 2 (2015): 600-606. https://doi.org/10.3892/ol.2015.3295