Open Access

Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival

  • Authors:
    • Yao Lu
    • Guo-Feng Guan
    • Jie Chen
    • Bin Hu
    • Cong Sun
    • Qiong Ma
    • Yan-Hua Wen
    • Xiu-Chun Qiu
    • Yong Zhou
  • View Affiliations

  • Published online on: July 24, 2015     https://doi.org/10.3892/ol.2015.3535
  • Pages: 2123-2129
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To determine the clinical significance of C-X-C chemokine receptor type 4 (CXCR4) and β-catenin in osteosarcoma, their protein expression levels were assessed in 96 osteosarcoma and 20 osteochondroma cases using immunohistochemistry. Additionally, CXCR4 and β‑catenin mRNA expression levels were measured in 16 fresh osteosarcoma and 16 adjacent healthy tissue samples using fluorescent reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). In the osteosarcoma samples, the positive CXCR4 protein expression rate was significantly higher than the rate in the osteochondroma samples (68.75 vs. 20.00%; P<0.01). Furthermore, β‑catenin protein expression was detected in 61.46% of osteosarcoma cases and 25.00% of osteochondroma cases. Similarly, the RT‑qPCR data identified increased CXCR4 and β‑catenin mRNA expression levels in the osteosarcoma compared with adjacent control tissues. It was determined that CXCR4 (P<0.01) and β‑catenin (P<0.05) expression were significantly associated with the clinical Enneking stage, metastasis and survival of osteosarcoma. Furthermore, multivariate analysis identified CXCR4 and β‑catenin protein expression levels, as well as clinical stage and metastasis, as significant risk factors for survival in patients with osteosarcoma (P<0.05). In conclusion, the present study determined that CXCR4 and β‑catenin are abnormally expressed in osteosarcoma tissues, and, therefore, may be important during osteosarcoma progression.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lu Y, Guan G, Chen J, Hu B, Sun C, Ma Q, Wen Y, Qiu X and Zhou Y: Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival. Oncol Lett 10: 2123-2129, 2015
APA
Lu, Y., Guan, G., Chen, J., Hu, B., Sun, C., Ma, Q. ... Zhou, Y. (2015). Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival. Oncology Letters, 10, 2123-2129. https://doi.org/10.3892/ol.2015.3535
MLA
Lu, Y., Guan, G., Chen, J., Hu, B., Sun, C., Ma, Q., Wen, Y., Qiu, X., Zhou, Y."Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival". Oncology Letters 10.4 (2015): 2123-2129.
Chicago
Lu, Y., Guan, G., Chen, J., Hu, B., Sun, C., Ma, Q., Wen, Y., Qiu, X., Zhou, Y."Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival". Oncology Letters 10, no. 4 (2015): 2123-2129. https://doi.org/10.3892/ol.2015.3535