Open Access

Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate

  • Authors:
    • Federico F. Cifuentes
    • Rodrigo H. Valenzuela
    • Héctor R. Contreras
    • Enrique A. Castellón
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  • Published online on: July 22, 2015     https://doi.org/10.3892/ol.2015.3522
  • Pages: 2142-2148
  • Copyright: © Cifuentes et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer is one of the most prevalent oncological diseases in males worldwide, and the mortalities resulting from this type of cancer are mainly due to metastasis. The most common models for the study of metastasis are transgenic and immunocompromised mice, which enable the study of the metastatic process in a controlled way by the injection of prostate cancer cells into the mice. In the present study, NOD‑SCIDγ mice were injected orthotopically with PC3 cells in the anterior prostate in order to establish a metastatic model. The results demonstrated the development and growth of a primary tumor that preceded the formation of micrometastases in the lung, liver and pancreas, followed by macrometastases in the liver. This model adequately represents the dynamics of the metastatic process, and may be useful for novel therapeutic assays and post-surgical relapse studies.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cifuentes FF, Valenzuela RH, Contreras HR and Castellón EA: Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate. Oncol Lett 10: 2142-2148, 2015
APA
Cifuentes, F.F., Valenzuela, R.H., Contreras, H.R., & Castellón, E.A. (2015). Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate. Oncology Letters, 10, 2142-2148. https://doi.org/10.3892/ol.2015.3522
MLA
Cifuentes, F. F., Valenzuela, R. H., Contreras, H. R., Castellón, E. A."Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate". Oncology Letters 10.4 (2015): 2142-2148.
Chicago
Cifuentes, F. F., Valenzuela, R. H., Contreras, H. R., Castellón, E. A."Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate". Oncology Letters 10, no. 4 (2015): 2142-2148. https://doi.org/10.3892/ol.2015.3522