Open Access

Clinicopathological and prognostic significance of metastasis-associated protein 1 expression and its correlation with angiogenesis in lung invasive adenocarcinomas, based on the 2011 IASLC/ATS/ERS classification

  • Authors:
    • Shuhai Li
    • Hui Tian
    • Weiming Yue
    • Lin Li
    • Cun Gao
    • Libo Si
    • Wensi Hu
    • Lei Qi
    • Ming Lu
    • Chuanle Cheng
    • Jingjing Cui
    • Guanqing Chen
  • View Affiliations

  • Published online on: October 29, 2015     https://doi.org/10.3892/ol.2015.3839
  • Pages: 224-230
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Based on previous findings regarding the angiogenic activities and prognostic roles of metastasis-associated protein 1 (MTA1) in early‑stage non‑small cell lung cancer, the clinicopathological and prognostic significance of MTA1 protein expression, and its correlation with angiogenesis in lung invasive adenocarcinoma, were further assessed in the present study, according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. High protein expression levels of MTA1 were commonly observed in patients with lung invasive adenocarcinoma, and were significantly correlated with tumor size (P=0.030), lymph node metastasis (P=0.021) and microvessel density (P=0.015). Survival analysis demonstrated that patients with high protein expression levels of MTA1 exhibited significantly shorter five‑year disease‑free and overall survival than those patients whose protein expression levels of MTA1 were low (24.5% vs. 48.7%, P=0.001, and 34.7% vs. 59.2%, P=0.005, respectively). In addition, Cox regression multivariate analysis demonstrated that high protein expression levels of MTA1 significantly correlated with unfavorable five‑year disease‑free survival (P=0.024). These findings indicate that MTA1 protein expression may possess clinical potential as an indicator of progressive phenotype. Therefore, MTA1 is a promising prognostic predictor to identify subgroups of patients with high risk of relapse, and a potentially novel therapeutic target for antiangiogenesis in patients with lung invasive adenocarcinoma.
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January-2016
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Spandidos Publications style
Li S, Tian H, Yue W, Li L, Gao C, Si L, Hu W, Qi L, Lu M, Cheng C, Cheng C, et al: Clinicopathological and prognostic significance of metastasis-associated protein 1 expression and its correlation with angiogenesis in lung invasive adenocarcinomas, based on the 2011 IASLC/ATS/ERS classification. Oncol Lett 11: 224-230, 2016
APA
Li, S., Tian, H., Yue, W., Li, L., Gao, C., Si, L. ... Chen, G. (2016). Clinicopathological and prognostic significance of metastasis-associated protein 1 expression and its correlation with angiogenesis in lung invasive adenocarcinomas, based on the 2011 IASLC/ATS/ERS classification. Oncology Letters, 11, 224-230. https://doi.org/10.3892/ol.2015.3839
MLA
Li, S., Tian, H., Yue, W., Li, L., Gao, C., Si, L., Hu, W., Qi, L., Lu, M., Cheng, C., Cui, J., Chen, G."Clinicopathological and prognostic significance of metastasis-associated protein 1 expression and its correlation with angiogenesis in lung invasive adenocarcinomas, based on the 2011 IASLC/ATS/ERS classification". Oncology Letters 11.1 (2016): 224-230.
Chicago
Li, S., Tian, H., Yue, W., Li, L., Gao, C., Si, L., Hu, W., Qi, L., Lu, M., Cheng, C., Cui, J., Chen, G."Clinicopathological and prognostic significance of metastasis-associated protein 1 expression and its correlation with angiogenesis in lung invasive adenocarcinomas, based on the 2011 IASLC/ATS/ERS classification". Oncology Letters 11, no. 1 (2016): 224-230. https://doi.org/10.3892/ol.2015.3839